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Items: 11

1.

The transcription factor, Nuclear factor, erythoid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development

(Submitter supplied) Development is a complex and well-defined process characterized by rapid cell proliferation and apoptosis. At this stage in life, a developmentally young organism is more sensitive to toxicants and other stressors when compared to an adult. In response to pro-oxidant exposure, members of the Cap’n’Collar (CNC) basic leucine zipper (b-ZIP) transcription factor family (including the Nfe2-related factors, Nrfs) activate the expression of genes that contribute to reduced toxicity. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
54 Samples
Download data: XLSX
Series
Accession:
GSE83466
ID:
200083466
2.

Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development

(Submitter supplied) The MTF-1 transcription factor is considered to be a master regulator of zinc homoestasis. We previously characterized a constitutively nuclear, dominant-negative zebrafish MTF-1/eGFP fusion protein (dnMTF-1). In this study, in vitro transcribed dnMTF-1 mRNA was microinjected into zebrafish embryos (2-cell stage), with controls consisting of zebrafish embryos (2-cell stage) microinjected with in vitro transcribed enhanced green fluorescent protein (eGFP) mRNA. more...
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL11077
16 Samples
Download data: TXT
Series
Accession:
GSE51298
ID:
200051298
3.

Nrf2b: a novel zebrafish paralog of the oxidant-responsive transcription factor Nrf2.

(Submitter supplied) We identified a novel paralog of the antioxidant response element transcription factor, Nrf2 in zebrafish. To determine whether the paralogs Nrf2a and Nrf2b regulate different sets of genes, we performed loss-of-function experiments followed by microarray-based gene expression profiling, performed on embryos in which expression of Nrf2a, Nrf2b, or both paralogs was knocked down.
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL14664
12 Samples
Download data: TXT
Series
Accession:
GSE32594
ID:
200032594
4.

Identification and developmental expression of the full complement of cytochrome P450 genes in zebrafish

(Submitter supplied) To determine the expression of cytochrome P450 genes during normal development
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL11077
24 Samples
Download data: TXT
Series
Accession:
GSE24840
ID:
200024840
5.

Altered gene expression in zebrafish embryos exposed to tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin

(Submitter supplied) Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis as well as to cardiovascular and neurodegenerative diseases. Developing animals may be especially sensitive to chemicals causing oxidative stress. To assess the response to chemicals at different stages of development, zebrafish (Danio rerio) embryos at 1, 2, 3, 4, 5, and 6 days post-fertilization (dpf) were exposed to 0.1% dimethyl sulfoxide (DMSO), 2 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or 10 uM tert-butylhydroquinone (tBHQ) for 6 hr. more...
Organism:
Danio rerio
Type:
Expression profiling by array
Platform:
GPL2878
12 Samples
Download data: TXT
Series
Accession:
GSE10157
ID:
200010157
6.

Gene expression profiling of Schistosoma mansoni larval development using serial analysis of gene expression (SAGE)

(Submitter supplied) Biomphalaria glabrata infection by the Schistosoma mansoni free-swimming miracidium and its subsequent development to the parasitic sporocyst stage is critical to establishment of viable infections and triggers a variety of physiological, biochemical and molecular changes. Here, we describe a genome-wide analysis of the S. mansoni miracidium and developing sporocyst. Keywords: life-cycle, development, host-interaction
Organism:
Schistosoma mansoni
Type:
Expression profiling by SAGE
Platform:
GPL5463
5 Samples
Download data
Series
Accession:
GSE9722
ID:
200009722
7.

Long Serial Analysis of Gene Expression (LongSAGE) of Chinook salmon (Oncorhynchus tshawytscha) brain tissue.

(Submitter supplied) Chinook salmon (Oncorhynchus tshawytscha) display the greatest variability of return times to freshwater of all Pacific salmon. Populations return to freshwater for spawning at many different times of year, resulting in segregated populations that may use differing molecular pathways for these large behavioral and physiological differences. Using a population of Chinook from California’s Central Valley, we sought to generate novel expressed sequences using Long Serial Analysis of Gene Expression (LongSAGE). more...
Organism:
Oncorhynchus tshawytscha
Type:
Expression profiling by SAGE
Platform:
GPL4407
3 Samples
Download data
Series
Accession:
GSE6009
ID:
200006009
8.

LongSAGE transcriptome profiling in the widespread marine coccolithophore Emiliania huxleyi

(Submitter supplied) The abundant and widespread coccolithophore Emiliania huxleyi plays an important role in mediating CO2 exchange between the ocean and the atmosphere through its impact on marine photosynthesis and calcification. Here, we use long serial analysis of gene expression (SAGE) to identify E. huxleyi genes responsive to nitrogen (N) or phosphorus (P) starvation. Long SAGE is an elegant approach for examining quantitative and comprehensive gene expression patterns without a priori knowledge of gene sequences via the detection of 21-bp nucleotide sequence tags. more...
Organism:
Emiliania huxleyi CCMP1516
Type:
Expression profiling by SAGE
Platform:
GPL5469
3 Samples
Download data
Series
Accession:
GSE8376
ID:
200008376
9.

In vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei

(Submitter supplied) The host range of African trypanosomes is influenced by innate protective molecules in the blood of primates. A subfraction of human high-density lipoprotein (HDL) containing apolipoprotein A-I, apolipoprotein L-I, and haptoglobin-related protein is toxic to Trypanosoma brucei brucei but not the human sleeping sickness parasite Trypanosoma brucei rhodesiense. It is thought that T. b. rhodesiense evolved from a T. more...
Organism:
Trypanosoma brucei brucei
Type:
Expression profiling by SAGE
Platform:
GPL5464
2 Samples
Download data
Series
Accession:
GSE8369
ID:
200008369
10.

Nitric oxide-dependent changes in Schistosoma mansoni gene expression

(Submitter supplied) Nitric oxide (NO) is a gaseous intercellular signaling molecule that also plays a role in host-parasite relations. NO acts rapidly, either via regulation of soluble guanylate cyclase, or by direct interactions with enzymes and other proteins, and has also been shown to have effects on gene expression. Here, we use SAGE (Serial Analysis of Gene Expression) to identify NO-responsive changes in gene expression in Schistosoma mansoni following a 3 hour exposure to sodium nitroprusside, an NO donor. more...
Organism:
Schistosoma mansoni
Type:
Expression profiling by SAGE
Platform:
GPL5463
2 Samples
Download data
Series
Accession:
GSE8366
ID:
200008366
11.

Characterization of the Giardia intestinalis Transcriptome

(Submitter supplied) Giardia gene expression is being examined using Serial Analysis of Gene Expression (SAGE) to monitor genome-wide levels of messenger RNA (mRNA) expression throughout Giardia's life cycle. Examination of genome-wide gene expression patterns will provide a coherent picture of activation and inactivation of biological pathways. This research will provide a comprehensive understanding of changes in giardial gene expression in response to important host physiological signals and will serve as a valuable model for study of other parasites and complex eukaryotes, such as yeast and animals. more...
Organism:
Giardia intestinalis
Type:
Expression profiling by SAGE
Platform:
GPL5454
10 Samples
Download data
Series
Accession:
GSE8336
ID:
200008336
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