GEO DataSet Links for SRA (Select 2791932) - GEO DataSets

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Items: 2

Select item 3022314191.

RNA_KO_2

Organism:: Mus musculus

Source name:: Mouse embryonic fibroblasts

Platform:: GPL17021
Series:: GSE66397 GSE84318

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Accession:: GSM2231419

ID:: 302231419

SRA Run Selector

Select item 2000843182.

MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density.

(Submitter supplied) Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C>T transitions resulting from spontaneous deamination of 5’-methylcytosine. Despite its significance, this DNA repair pathway is still poorly understood. Here we show that the protein MBD4 is required for DNA methylation maintenance and G/T mismatch repair. more...