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Systematic dissection of regulatory motifs in 2,000 predicted human enhancers using a massively parallel reporter assay

(Submitter supplied) We employ a massively parallel reporter assay (MPRA) to measure the ex vivo activities of hundreds of K562 and HepG2 enhancers with known transcription factor motif instances. For seven selected motifs that correspond to known or predicted activators and repressors in the two cell types, we make directed modifications of the bases corresponding to these motifs and observe the changes in enhancer activity.
Homo sapiens; Escherichia coli
GPL11154 GPL14548
6 Samples
Download data: TXT

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