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Items: 2

1.

Gene expression profiling of in vitro derived induced and natural FOXP3+ regulatory T cells and ex-iTreg cells in the mouse

(Submitter supplied) Induced Treg (iTreg) cells are essential for tolerance and can be used therapeutically, yet their stability in vivo and mechanisms of suppression are unresolved. Here, we used a treatment model of colitis to examine the role of autologous IL-10 in iTreg cell function. Mice treated with IL-10+/+ iTreg cells in combination with IL-10–/– natural Treg (nTreg) cells survived and gained weight, even though iTreg cells were numerically disadvantaged and comprised just ~20% of all Treg cells in treated mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4364
Platform:
GPL1261
6 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE35543
ID:
200035543
2.
Full record GDS4364

Natural and induced Foxp3+ regulatory T cells and Foxp3-deficient induced regulatory T cells

Analysis of 3 subsets of sorted Tregs: natural (nTreg), induced (iTreg), and iTregs that lost Foxp3 expression (ex-iTreg), from spleens and mesenteric lymph nodes of BALB/c Rag1-/- mice treated with WT nTregs and WT iTregs. Results provide insight into molecular relationships among the Treg subsets.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 cell type sets
Platform:
GPL1261
Series:
GSE35543
6 Samples
Download data:
GEO (CEL)

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