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Synthetic lethal screening with small molecule inhibitors provides a pathway to rational combination therapies for melanoma

(Submitter supplied) Recent data demonstrate that extracellular signals are transmitted through a network of proteins rather than hierarchical signaling pathways. This network model suggests why inhibition of a single component of a canonical pathway, even when targeting a mutationally activated driver of cancer, has insufficiently dramatic effects on the treatment of cancer. The biological outcome of signals propagated through a network is inherently more robust and resistant to inhibition of a single network component due to compensatory and redundant signaling events. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
24 Samples
Download data
Series
Accession:
GSE39192
ID:
200039192

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