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Items: 2

1.

Expression data from murine fibroblasts overexpressing Fbxl10

(Submitter supplied) Posttranslational modifications on histone tails control gene expresssion levels in an either positive or negative way. Therefore enzymes which modifiy the modifications on the histon tails, like histone demethylases, are able to strictly regulate the transcriptom. To analyse the regulatory role of histone demethylase Fbxl10 we generated a stable cell line permanently overexpressing HA-tagged Fbxl10 and identified the transcriptome changes compared to untransfected control cell line by microarray.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4788
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE34691
ID:
200034691
2.
Full record GDS4788

H3K4me3 histone demethylase Fbxl10 overexpression effect on fibroblast cell line

Analysis of MEF cell line stably overexpressing Fbxl10. Stable overexpression of Fbxl10 leads to an increase in cell size but no changes to proliferation, mitosis, apoptosis, or global histone marks. Results provide insight into the regulatory role of Fbx110 in fibroblasts.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL6246
Series:
GSE34691
6 Samples
Download data: CEL, CHP

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