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Items: 4

1.

DNA methylation differences between Newborns and Nonagenarians [PBMNC]

(Submitter supplied) Human aging implies many phenotypic modifications and an increased susceptibility to many common diseases, phenomena that cannot be fully explained by the constrained genetic setting. An alternative pathway that could explain the age-associated alterations is epigenetic drifts. To address this issue, we performed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and of a centenarian. The centenarian DNA exhibited a significant loss in DNA methylation and a poor correlation in the methylation status of neighboring CpGs throughout the genome. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL13534
19 Samples
Download data: TXT
Series
Accession:
GSE33233
ID:
200033233
2.

The DNA Methylomes of a Newborn and a Centenarian

(Submitter supplied) Examination of two DNA methylomes at the most extreme points of their lives to see differences that might contribute to explain the aged phenotype
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL14157
14 Samples
Download data: TXT
Series
Accession:
GSE31438
ID:
200031438
3.

The DNA methylomes of a newborn and a centenarian

(Submitter supplied) We have developed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and a centenarian to address the epigenetic drifts in human aging, which might be an alternative pathway to explain the age-associated alterations. In addition, we have analyzed the methylome of a middle-age donor (26 years).
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platforms:
GPL11154 GPL9052
3 Samples
Download data: BED
Series
Accession:
GSE31263
ID:
200031263
4.

DNA methylomes of Newborns and Nonagenarians

(Submitter supplied) DNA methylation differences between Newborns and Nonagenarians
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL13534
40 Samples
Download data: TXT
Series
Accession:
GSE30870
ID:
200030870
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