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Items: 2

1.

IL-17A is an essential cytokine to sustain pathogenic cell activation and inflammatory gene circuits in psoriasis vulgaris

(Submitter supplied) In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies in model systems indicate that IL-22 has a dominant pathogenic role, there is evolving evidence that IL-17 contributes to features of psoriasis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4458
Platform:
GPL571
30 Samples
Download data: CEL
Series
Accession:
GSE31652
ID:
200031652
2.
Full record GDS4458

Anti-IL-17 monclonal antibody ixekizumab effect on chronic psoriasis

Analysis of psoriatic skin biopsies from patients treated with 150mg of subcutaneous anti-IL-17 mAb ixekizumab (previously LY2439821) at weeks 0 and 2. IL-17 blockade resulted in a high-grade clinical improvement in psoriasis. Results provide insight into the role of IL-17 in disease pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 17 individual, 2 time sets
Platform:
GPL571
Series:
GSE31652
30 Samples
Download data: CEL

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