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Systemic elevation of PTEN induces a tumor suppressive metabolic state

(Submitter supplied) Decremental loss of PTEN results in cancer susceptibility and tumor progression. In turn this raises the possibility that PTEN elevation might be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines with variably elevated PTEN expression levels, taking advantage of BAC (Bacterial Artificial Chromosome)-mediated transgenesis. Super-PTEN mutants are viable and show reduced body size due to decreased cell number, with no effect on cell size. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE35670
ID:
200035670

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