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Probing sporadic and familial Alzheimer?s disease using induced pluripotent stem cells.

(Submitter supplied) Our understanding of Alzheimer’s disease (AD) pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of AD. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cells (iPSCs). We reprogrammed primary fibroblasts from two patients with familial AD (both caused by a duplication of APP1, APPDp), two with sporadic AD (sAD1, 2) and two non-demented control individuals (NDCs) into iPSC lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
38 Samples
Download data: TXT
Series
Accession:
GSE34879
ID:
200034879

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