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Items: 2

1.

Mutant p53 Disrupts Mammary Acinar Morphogenesis via the Mevalonate Pathway

(Submitter supplied) p53 is a frequent target for mutation in human tumors and previous studies have revealed that these missense mutant proteins can actively contribute to tumorigenesis. To elucidate how mutant p53 might contribute to mammary carcinogenesis we employed a three-dimensional (3D) culture model. In 3D culture non-malignant breast epithelial cells form structures reminiscent of acinar structures found in vivo, whereas breast cancer cells form highly disorganized and in some cases invasive structures. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4096
Platform:
GPL6244
6 Samples
Download data: CEL, XLS
Series
Accession:
GSE31812
ID:
200031812
2.
Full record GDS4096

Mutant p53 depletion effect on MDA-468.shp53 breast tumor cell line

Analysis of MDA-468.shp53 cells cultured under 3D conditions in the presence of DOX. These cells express a DOX-inducible shRNA targeting endogenous mutant p53. The p53-reduced cells have an invasive, highly disorganized appearance. Results provide insight into role of mutant p53 in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 growth protocol sets
Platform:
GPL6244
Series:
GSE31812
6 Samples
Download data: CEL

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