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Items: 4

1.

MicroRNA expression in primate postnatal brain through lifespan

(Submitter supplied) While multiple studies have reported the accelerated evolution of brain gene expression in the human lineage, the mechanisms underlying such change remain poorly understood. Here we address this issue from a developmental perspective, by analyzing mRNA and microRNA (miRNA) expression in two brain regions within macaques, chimpanzees and humans throughout their lifespan. We find that developmental profiles of trans-regulators, such as miRNA, as well as their target genes, show the fastest rates of human-specific evolutionary change. more...
Organism:
Macaca mulatta; Homo sapiens; Pan troglodytes
Type:
Non-coding RNA profiling by array
Platform:
GPL10850
64 Samples
Download data: TXT
Series
Accession:
GSE29356
ID:
200029356
2.

Gene expression in primate postnatal brain through lifespan

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Macaca mulatta; Pan troglodytes; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
130 Samples
Download data: CEL
Series
Accession:
GSE22570
ID:
200022570
3.

Gene expression in primate postnatal brain through lifespan - cerebellar cortex

(Submitter supplied) We investigated molecular changes during human, chimpanzee, and rhesus macaque postnatal brain development at the transcriptome, proteome, and metabolome levels in two brain regions: the prefrontal cortex (PFC) that is involved in several human-specific cognitive processes, and the cerebellar cortex (CBC) that may be functionally more conserved. We find a nearly three-fold excess of human-specific gene expression changes in PFC compared to CBC. more...
Organism:
Homo sapiens; Macaca mulatta; Pan troglodytes
Type:
Expression profiling by array
Platform:
GPL6244
62 Samples
Download data: CEL
Series
Accession:
GSE22569
ID:
200022569
4.

Gene expression in primate postnatal brain through lifespan - prefrontal cortex

(Submitter supplied) We investigated molecular changes during human, chimpanzee, and rhesus macaque postnatal brain development at the transcriptome, proteome, and metabolome levels in two brain regions: the prefrontal cortex (PFC) that is involved in several human-specific cognitive processes, and the cerebellar cortex (CBC) that may be functionally more conserved. We find a nearly three-fold excess of human-specific gene expression changes in PFC compared to CBC. more...
Organism:
Pan troglodytes; Macaca mulatta; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
68 Samples
Download data: CEL, TSV
Series
Accession:
GSE22521
ID:
200022521
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