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Items: 3

1.

CREB3L1 Target Genes in Response to Hepatitis C Replicon Infection

(Submitter supplied) Membrane-bound transcription factor CREB3L1 undergoes Regulated Intramembrane Proteolysis (RIP) in response to Hepatitis C infection. RIP activates CREB3L1 so that it can prevent the growth of HCV infected cells through the action of downstream genes. We over-expressed a truncated form of CREB3L1 that does not require RIP to enter the nucleus. Cells over-expressing this truncated form were isolated by Fluorescence Activated Cell Sorting (FACS). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
2 Samples
Download data:
GEO (CEL, CHP)
Series
Accession:
GSE25157
ID:
200025157
2.

Host Factors with Reduced Expression in Two HCV Permissive Cell Lines as Compared to the Non-Permissive Parent Cell Line Huh7

(Submitter supplied) Drugs directly targeting Hepatitis C (HCV) are often rendered useless by the high mutation rate of the virus. Thus, we deduce that targeting of host factor that affect HCV replication may provide enhanced therapy fort HCV infection. Hepatocyte cell line Huh7 is known to be non-permissive for Hepatits C (HCV) replication. Through a method developed by the Rice laboratory (Blight, K.J., et al., J Virol, 2002), selection of a small subset of permissive hepatocytes is possible. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4392
Platform:
GPL570
4 Samples
Download data:
GEO (CEL, CHP)
Series
Accession:
GSE25156
ID:
200025156
3.
Full record GDS4392

Hepatitis C virus permissive cell lines Huh7.5 and HRP1 and non-permissive parent cell line Huh7

Analysis of hepatocyte cell line Huh7, non-permissive to hepatitis C virus (HCV) replication, and permissive cell lines Huh7.5 and HRP1. Results provide insight into host factors lost in cells permissive for HCV replication.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 cell line, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE25156
4 Samples
Download data:
GEO (CEL, CHP)
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