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Items: 2

1.

Chromatin and Transcriptional Signatures for Nodal Signaling During Endoderm Formation in hESCs

(Submitter supplied) To elucidate the Nodal transcriptional network that governs endoderm formation, we used ChIP-Seq to identify genomic targets for SMAD2/3, SMAD3, SMAD4, FOXH1 and the active and repressive chromatin marks, H3K4me3 and H3K27me3, in human embryonic stem cells (hESCs) and derived endoderm. We demonstrate that while SMAD2/3, SMAD4 and FOXH1 target binding is highly dynamic, there is an optimal signature for driving endoderm commitment. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
18 Samples
Download data: BED, TXT, WIG
Series
Accession:
GSE29422
ID:
200029422
2.

Expression data from human embryonic stem cells (hESCs) and Activin-induced/derived cells

(Submitter supplied) Nodal/Activin signaling directs mesendoderm specification in early vertebrate embryogenesis. We have characterized transcriptional profiling of human embryonic stem cells and Activin-treated cells at different timepoints. In this dataset, we include the timecourse gene expression data obtained from hESC differentiation post Activin treatment, examining at day 0, 1, 3 and 5.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
16 Samples
Download data: CEL
Series
Accession:
GSE29421
ID:
200029421

Supplemental Content

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