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Items: 2

1.

HDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells

(Submitter supplied) Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ Tregs express histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression and protein function. Pan-HDAC inhibitors developed for oncology enhance Treg production and suppression but have limited non-oncologic applications given their broad effects. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4375
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE27896
ID:
200027896
2.
Full record GDS4375

Histone/protein deacetylase (HDAC) 6-deficient CD4+CD25+ T-regulatory cells

Analysis of CD4+CD25+ T-regulatory cells (Treg) from HDAC6-deficient C57BL6 mice. Foxp3+ Tregs are key to immune homeostasis and express multiple HDACs. Results provide insight into the role of the HDAC6 isoform in the suppressive functions of Foxp3+ Tregs.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE27896
6 Samples
Download data: CEL

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