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Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription

(Submitter supplied) Insulin (INS) synthesis and secretion from pancreatic β cells are tightly regulated; their deregulation causes diabetes. Here we map INS-associated loci in human pancreatic islets by 4C and 3C techniques and show that the INS gene physically interacts with the SYT8 gene, located over 300 kb away. This interaction is elevated by glucose and accompanied by increases in SYT8 expression. Inactivation of the INS promoter by promoter-targeting siRNA reduces SYT8 gene expression. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL9052
2 Samples
Download data: BED, GRAPH
Series
Accession:
GSE25862
ID:
200025862

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