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Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells

(Submitter supplied) After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading to antibody class switch recombination (CSR). Using a candidate approach, AID has been shown to initiate mutations at numerous non-Ig genes in B cells in Peyer’s patches. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
10 related Platforms
60 Samples
Download data: PAIR
Series
Accession:
GSE24827
ID:
200024827

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