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Items: 2

1.

Long-range expression effects of CNV: insights from Smith-Magenis and Potocki-Lupski syndrome mouse model

(Submitter supplied) To study the effect of structural changes on expression, we assessed gene expression in genomic disorder mouse models. Both a microdeletion and its reciprocal microduplication mapping to mouse chromosome 11 (MMU11), which model the rearrangements present in Smith-Magenis (SMS) and Potocki-Lupski (PTLS) syndromes patients, respectively, have been engineered. We profiled the transcriptome of five different tissues affected in human patients in mice with 1n (Deletion/+), 2n (+/+), 3n (Duplication/+) and uniallelic 2n (Deletion/Duplication) copies of the same region in an identical genetic background. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
61 Samples
Download data: CEL
Series
Accession:
GSE14802
ID:
200014802
2.

Copy number variation and gene expression in the mouse

(Submitter supplied) Copy number variation (CNV) of DNA segments has recently been identified as a major source of genetic diversity, but a more comprehensive understanding of the extent and phenotypic effect of this type of variation is only beginning to emerge. In this study we generated genome-wide expression data from 6 mouse tissues to investigate how CNVs influence gene expression. Keywords: genetic background, gene expression profiling
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
108 Samples
Download data: CEL
Series
Accession:
GSE10744
ID:
200010744

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