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Hdac3 is essential for the maintenance of chromatin structure and genome stability

(Submitter supplied) Deletion of Hdac3 impaired DNA repair and greatly reduced chromatin compaction and heterochromatin content. Liver-specific deletion of Hdac3 culminated in hepatocellular carcinoma. The loss of genomic stability and the impaired response to DNA damage suggested that a high mutation rate stimulated the development of HCC. To begin to assess what pathways were involved in the formation of HCC, we performed gene expression analysis using cDNA microarrys. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
5 Samples
Download data: CEL
Series
Accession:
GSE22457
ID:
200022457

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