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Items: 2

1.

A compendium of myeloma associated chromosomal copy number abnormalities and their prognostic value

(Submitter supplied) To obtain a comprehensive genomic profile of presenting multiple myeloma cases we performed high resolution single nucleotide polymorphism (SNP) mapping array analysis in 114 samples alongside 258 samples analysed by U133 Plus 2.0 expression array (Affymetrix). We examined DNA copy number alterations and loss of heterozygosity (LOH) in order to define the spectrum of minimally deleted regions in which relevant genes of interest can be found. more...
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array; Expression profiling by array
Platforms:
GPL570 GPL3720 GPL3718
491 Samples
Download data: CEL, CHP
Series
Accession:
GSE21349
ID:
200021349
2.

Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of human multiple myeloma

(Submitter supplied) We have used genome-wide methylation microarrays to analyze differences in CpG methylation patterns in cells relevant to the pathogenesis of myeloma plasma cells, including B cells, normal plasma cells, MGUS, presentation myeloma, and plasma cell leukemia (PCL). We show that methylation patterns in these cell types are capable of distinguishing non-malignant from malignant cells and that the main reason for this difference is hypomethylation of the genome at the transition from MGUS to presentation myeloma. more...
Organism:
Homo sapiens
Type:
Methylation profiling by array
Platform:
GPL8490
190 Samples
Download data
Series
Accession:
GSE21304
ID:
200021304

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