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Items: 2

1.

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia

(Submitter supplied) The NF-κB pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-κB response is regulated by the activation state of the IκB kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported that NF-κB is downstream of Notch1 in T cell acute lymphoblastic leukaemia (T-ALL), however both the mechanisms involving Notch1-induced NF-κB activation and the potential importance of NF-κB in the maintenance of the disease are unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4213
Platform:
GPL570
20 Samples
Download data: CEL
Series
Accession:
GSE20667
ID:
200020667
2.
Full record GDS4213

NF-kB inactivation effect on T-ALL1 cell lines

Analysis of T cell acute lymphoblastic leukemia (T-ALL) cell lines treated with a peptide that inhibits the activity of IKK, an activator of NF-kB. NF-kB pathway is downstream of oncogenic Notch1 in T-ALL. Results provide insight into the molecular basis of Notch-induced NF-kB activation in T-ALL.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 5 cell line sets
Platform:
GPL570
Series:
GSE20667
20 Samples
Download data: CEL

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