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Items: 2

1.

H3K27 Methyltransferase PRC2 Represses Wnt Genes to Facilitate Adipogenesis

(Submitter supplied) The Wnt/b-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase PRC2 on Wnt genes. However, the functional significance of such a direct link between the two types of developmental regulators in mammalian cells, and the role of PRC2 in adipogenesis, remain unclear. Here we show PRC2 and its H3K27 methyltransferase activity are required for adipogenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3765
Platform:
GPL1261
4 Samples
Download data:
GEO (CEL)
Series
Accession:
GSE20054
ID:
200020054
2.
Full record GDS3765

Histone H3K27 methyltransferase Ezh2 deletion effect on primary preadipocyte cultures

Analysis of preadipocytes deficient in Ezh2, the enzymatic subunit of H3K27 methyltransferase PRC2. Deletion of Ezh2 eliminates H3K27me3 on Wnt promoters leading to activation of Wnt/b-catenin signaling and inhibition of adipogenesis. Results provide insight into the role of PRC2 in adipogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE20054
4 Samples
Download data:
GEO (CEL)

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