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Items: 2

1.

S1P lyase deficiency disrupts lipid homeostasis in liver

(Submitter supplied) The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway. We have studied mice with an inactive S1P lyase gene and have found that, in addition to the expected increase of sphingoid base phosphates, other sphingolipids (including sphingosine, ceramide, and sphingomyelin) were substantially elevated in the serum and /or liver of these mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3654
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE18745
ID:
200018745
2.
Full record GDS3654

Sphingosine 1-phosphate lyase deficiency effect on liver

Analysis of liver of animals lacking sphingosine 1-phosphate lyase (S1P). In addition to the expected increase of sphingoid base phosphates, other sphingolipids are elevated in the sera and livers of S1P deficient animals. Results provide insight into the role of S1P in lipid metabolic pathways.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE18745
6 Samples
Download data: CEL, CHP

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