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Genome-wide DNA methylation profiling of Acute Myeloid Leukemia

(Submitter supplied) We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11 and PML-RARA leukemia entities are associated with specific methylation profiles. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL6604
352 Samples
Download data: PAIR
Series
Accession:
GSE18700
ID:
200018700

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