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Items: 4

1.

Mice with fibrinogen-induced arthritis (FIA)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Protein profiling by protein array
Platforms:
GPL9165 GPL9163
23 Samples
Download data: GPR
Series
Accession:
GSE18073
ID:
200018073
2.

Fibrinogen-reactive T cells transfer disease to naïve mice

(Submitter supplied) Splenocytes harvested from mice with FIA were cultured in vitro and stimulated with 0.01 mg/ml fibrinogen for 3 days. Enriched T cells were transferred into 6-week-old naïve SJL mice, which developed visible signs of arthritis within 2 weeks. Synovial array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B cell responses against peptides representing native fibrinogen, and further spreading of the responses to target collagen type V, cartilage gp39, and citrullinated vimentin. more...
Organism:
Homo sapiens; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL9165
9 Samples
Download data: GPR
Series
Accession:
GSE18025
ID:
200018025
3.

FIA plasma induces arthritis in naïve mice

(Submitter supplied) Plasma collected from mice with FIA were pooled, and 0.3 ml was injected intravenously into 6-week-old naïve SJL mice on days 0 and 2. Synovial antigen array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B-cell responses against peptides representing native fibrinogen and citrullinated fibrinogen, and further epitope spreading resulting in additional targeting of fibronectin, collagen type V, cartilage gp39, and clusterin.
Organism:
Mus musculus; Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL9165
8 Samples
Download data: GPR
Series
Accession:
GSE18024
ID:
200018024
4.

Mice with FIA develop anti-native and anti-in vitro citrullinated fibrinogen antibodies

(Submitter supplied) Synovial antigen arrays were probed with 1:150 dilutions of plasma derived from SJL mice immunized with fibrinogen emulsified in CFA or with CFA alone. Autoantibody binding was detected with a Cy3-conjugated goat-anti-mouse IgG/M secondary antibody. SAM was applied to identify antigens with statistically significant differences in array reactivity between FIA and CFA control plasma (q < 0.01) obtained from mice before boosting. more...
Organism:
Homo sapiens; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL9163
10 Samples
Download data: GPR
Series
Accession:
GSE18023
ID:
200018023
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