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DNA methylation programming and reprogramming in primate embryonic stem cells

(Submitter supplied) DNA methylation is an important epigenetic mechanism, affecting normal development and playing a key role in reprogramming epigenomes during stem cell derivation. Here we report on DNA methylation patterns in native monkey embryonic stem (ES) cells, fibroblasts and ES cells generated through somatic cell nuclear transfer (SCNT), identifying and comparing epigenome programming and reprogramming. We characterize hundreds of regions that are hyper- or hypo- methylated in fibroblasts compared to native ES cells and show that these are conserved in human cells and tissues. more...
Organism:
Macaca mulatta
Type:
Methylation profiling by genome tiling array
Platform:
GPL9155
12 Samples
Download data:
GEO (PAIR)
Series
Accession:
GSE17981
ID:
200017981

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