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Items: 2

1.

Loss of Syk in normal breast cells

(Submitter supplied) Loss of Syk in normal breast cells in vivo and in vitro: gene expression and phenotypic switch to stem-cell like with induction of invadopodia Morphological and gene microarray analysis following Syk knockdown in MCF10A reveals a loss of luminal and differentiated epithelial features with epithelial to mesenchymal transition and a gain in invadopodia and stem/ progenitor cell marker expression. These results support the role of Syk in limiting normal stem/progenitor proliferation and invasion during morphogenesis, and support the role of Syk as a critical tumor suppressor for breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3609
Platform:
GPL571
12 Samples
Download data: CEL
Series
Accession:
GSE16200
ID:
200016200
2.
Full record GDS3609

Syk depletion effect on breast epithelial cell line

Analysis of MCF10A breast epithelial cells depleted for Syk. Progressive loss of Syk mRNA occurs during breast tumor development. Results provide insight into Syk’s tumor suppressor function and role in normal breast development.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 growth protocol, 2 protocol sets
Platform:
GPL571
Series:
GSE16200
12 Samples
Download data: CEL

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