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Items: 2

1.

Rhesus monkeys challenged with H. pylori and ENNG

(Submitter supplied) Gene expression was studied in samples from the stomach of Rhesus monkeys that have been infected with Helicobacter pylori and treated with a known carcinogen (Ethyl-nitro-nitrosoguanidine (ENNG)) that is similar to known nitrosamine dietary carcinogens. The samples represent the following: Biopsy 4689 is from animal 81G taken 55 months after inoculation with H. pylori and the start of the carcinogen ENNG Biopsy 4691 is from animal 63G taken 55 months after inoculation with H. more...
Organism:
Macaca mulatta
Type:
Expression profiling by array
Platform:
GPL9861
3 Samples
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Series
Accession:
GSE38586
ID:
200038586
2.

Diet Synergistically Affects Helicobacter pylori-Induced Gastric Carcinogenesis in Nonhuman Primates

(Submitter supplied) BACKGROUND & AIMS: Gastric cancer results from a combination of Helicobacter pylori (H pylori) infection, exposure to dietary carcinogens, and predisposing genetic make-up. Because the role of these factors in gastric carcinogenesis cannot be determined readily in human beings, the present study examined the role of an oral carcinogen and H pylori infection in rhesus monkeys. METHODS: Gastroscopies were performed in 23 monkeys assigned to 4 groups: controls; nitrosating carcinogen ethyl-nitro-nitrosoguanidine administration alone; and inoculation of a virulent H pylori strain alone (H), or in combination with ethyl-nitro-nitrosoguanidine (EH). more...
Organism:
Macaca mulatta
Type:
Expression profiling by array
Platform:
GPL9360
21 Samples
Download data
Series
Accession:
GSE18434
ID:
200018434

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