Format

Send to:

Choose Destination

Links from PubMed

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage

(Submitter supplied) The Mre11 complex (Mre11, Rad50, and Nbs1) and Chk2 have been implicated in the DNA damage response, an inducible process required for the suppression of malignancy. The Mre11 complex is predominantly required for repair and checkpoint activation in S phase, while Chk2 governs apoptosis. We examined the relationship between the Mre11 complex and Chk2 in the DNA damage response via the establishment of Nbs1∆B/∆B Chk2-/- and Mre11ATLD1/ATLD1 Chk2-/- mice. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE11436
ID:
200011436

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center