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Items: 2

1.

Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression

(Submitter supplied) Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma. Cultures of normal human melanocytes (NHMs) and melanoma lines were analyzed to determine whether global patterns of gene expression could predict the efficacy of DNA damage cell cycle checkpoints that arrest growth and suppress genetic instability. NHMs displayed effective G1 and G2 checkpoint responses to ionizing radiation-induced DNA damage. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1708
23 Samples
Download data: TXT
Series
Accession:
GSE7469
ID:
200007469
2.

Identification of Primary Transcriptional Regulation of Cell-Cycle-Regulated Genes upon DNA Damage

(Submitter supplied) The changes in global gene expression in response to DNA damage may derive from either direct induction or repression by transcriptional regulation or indirectly by synchronization of cells to specific cell cycle phases, such as G1 or G2. We developed a model that successfully estimated the expression levels of >400 cell-cycle-regulated genes in normal human fibroblasts based on the proportions of cells in each phase of the cell cycle. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL885 GPL887
54 Samples
Download data: TXT
Series
Accession:
GSE7075
ID:
200007075

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