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A small RNA mechanism distinct from the RNAi and microRNA pathways silences selfish genetic elements in Drosophila.

(Submitter supplied) In flies, repeat-associated small interfering RNAs (rasiRNAs) ensure genomic stability by silencing endogenous selfish genetic elements such as retrotransposons and repetitive sequences. Here, we show that while small interfering RNAs (siRNAs) derive from both the sense and antisense strands of their double-stranded RNA precursors, rasiRNAs arise mainly from the antisense strand. rasiRNA production appear not to require Dicer-1, which makes microRNAs, or Dicer-2, which makes siRNAs, and rasiRNAs lack the 2´,3´ hydroxy termini characteristic of animal siRNA and miRNA. more...
Organism:
Drosophila melanogaster
Type:
Non-coding RNA profiling by array
10 related Platforms
10 Samples
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Series
Accession:
GSE4932
ID:
200004932

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