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PDGF-induced genes regulated by the PI3K and MEK/ERK signaling pathways

(Submitter supplied) Human T98G glioblastoma cells were stimulated with platelet-derived growth factor (PDGF) and analyzed by DNA microarrays, which identified 74 immediate-early gene transcripts. Cells were then treated with inhibitors to identify subsets of genes that are targets of the phosphatidylinositol 3-kinase (PI3K) and MEK/ERK signaling pathways. Four groups of PDGF-induced genes were defined: independent of PI3K and MEK/ERK signaling, dependent on PI3K signaling, dependent on MEK/ERK signaling, and dependent on both pathways. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL876 GPL875
11 Samples
Download data: TIFF
Series
Accession:
GSE1128
ID:
200001128

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