GEO DataSets

Identification of aging-dependent cognitive decline gene expression. Hippocampal CA1 tissue collected from 4, 14, and 24 month old male Fischer 344 rats after 7 days training on water maze and object memory task.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL85

Series:

GSE854

29 Samples

Download data: CEL, TXT

(Submitter supplied) Male Fischer 344 rats aged 4 months (young, n=10), 14 months (mid-aged, n=10), and 24 months (aged, n=10) were trained sequentially on two tasks: Morris Spatial Water Maze (SWM) and Object Memory Task (OMT). The training/testing sequence lasted 7 d, and hippocampal tissue was collected 24 hr later. Training and testing occured on each day except for days 2 and 3 of the 7 d sequence. (01/10/05: Series was updated to correct mislabeling of all sample signal values within the Young Treatment Group) Keywords = bioinformatics Keywords = gene expression Keywords = memory Keywords = synaptic plasticity Keywords = myelin Keywords = inflamation Keywords = aging Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS520

Platform:

GPL85

29 Samples

Download data: CEL, TXT

(Submitter supplied) Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways associated with aging-related cognitive impairment. Aged rats were separated into cognitively unimpaired (AU) or impaired (AI) groups, based on their Morris water maze performance relative to young-adult (Y) animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2639

Platform:

GPL341

78 Samples

Download data: CEL, EXP, XLS

Analysis of hippocampi from aged learning-impaired animals on the last day of training in the Morris water maze (MWZ) or 21 days post-training. The MWZ task is a dorsal hippocampal-dependent task. Results provide insight into the molecular basis of aging-related cognitive impairment.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 3 disease state, 3 protocol sets

Platform:

GPL341

Series:

GSE5666

78 Samples

Download data: CEL, EXP

(Submitter supplied) Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3915

Platform:

GPL341

49 Samples

Download data: CEL

Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age sets

Platform:

GPL341

Series:

GSE9990

49 Samples

Download data: CEL

(Submitter supplied) The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris water maze, when compared to young rats. Then we isolated messenger RNA from the dentate gyrus of the hippocampus of each animal to interrogate Affymetrix RAE 230A rat genome microarrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

79 Samples

Download data

(Submitter supplied) Background: Age-related cognitive deficits negatively affect quality of life and can presage serious neurodegenerative disorders. Despite sleep disruption’s well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies have tested sleep’s relationship to cognitive aging. Methodology: We measured sleep stages in young adult and aged F344 rats during inactive (enhanced sleep) and active (enhanced wake) periods. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3939

Platform:

GPL1355

12 Samples

Download data: CEL

Analysis of parietal cortices of young and aged F344 males implanted with telemetry devices to measure sleep architecture. Animals were trained in the Morris water maze to assess cognitive function. Results provide insight into possible mechanistic links between sleep changes and cognitive aging.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 6 specimen sets

Platform:

GPL1355

Series:

GSE24515

12 Samples

Download data: CEL

(Submitter supplied) The project examined age-related change in hippocampal gene expression in Fisher 344 x Brown Norway F1 rats from the NIA aging colony (Adult = 12M, Aged = 24M). CA1, CA3, and DG specific dissections were examined from one cohort of animals and from a second cohort whole hippocampus was used.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

60 Samples

Download data: TXT

(Submitter supplied) Hippocampal overexpression of FK506-binding protein 12.6/1b (FKBP1b), a negative regulator of ryanodine receptor Ca2+ release, reverses aging-induced memory impairment and neuronal Ca2+ dysregulation. Here, we test the hypothesis that FKBP1b also can protect downstream transcriptional networks from aging-induced dysregulation. We gave hippocampal microinjections of FKBP1b-expressing viral vector to male rats at either 13-months-of-age (long-term) or 19-months-of-age (short-term) and tested memory performance in the Morris water maze at 21-months-of-age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

23 Samples

Download data: CEL

(Submitter supplied) Previous studies of age-related transcriptional changes indicate that cognitive impairments are associated with differentially expressed genes DEGs linked to defined neural systems; however, studies that examine multiple regions of the hippocampus fail to find major links between behavior and transcription in the dentate gyrus DG. The DG is implicated in pattern separation PS and exhibits multiple age-related changes that may affect PS performance. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19482 GPL27757

84 Samples

Download data: CSV

(Submitter supplied) The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris Water Maze and then isolated messenger RNA from the CA1 hippocampal region of each animal to interrogate Affymetrix microarrays. Microarray analysis (p<0.005) identified a set of 50 genes that were transcribed differently in age-unimpaired animals that had successfully learned a spatial task compared to aged learning-impaired animals and a variety of groups designed to control for all non-learning aspects of exposure to the water maze paradigm. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

79 Samples

Download data

(Submitter supplied) We carried out a global survey of age-related changes in mRNA levels in the C57BL/6NIA mouse hippocampus and found a difference in the hippocampal gene expression profile between 2-month-old young mice and 15-month-old middle-aged mice correlated with an age-related cognitive deficit in hippocampal-based explicit memory formation. Middle-aged mice displayed a mild but specific deficit in spatial memory in the Morris water maze. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2082

Platform:

GPL81

23 Samples

Download data

Analysis of hippocampi of 2-month-old young and 15-month-old middle-aged animals. The hippocampal formation is one of the brain areas most affected by aging. Results provide insight into molecular changes accompanying the early stages of age-related memory decline.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL81

Series:

GSE5078

23 Samples

Download data

(Submitter supplied) Environmental enrichment has been reported to delay or restore age-related cognitive deficits, however, a mechanism to account for the cause and progression of normal cognitive decline and its preservation by environmental enrichment is lacking. Using genome-wide SAGE-Seq, we provide a global assessment of differentially expressed genes altered with age and environmental enrichment in the hippocampus. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14602

12 Samples

Download data: XLSX

(Submitter supplied) The aim of this study was to examine the hippocampus, frontal cortex and dorsal raphe of Dark Agouti rats with gene expression arrays (Illumina RatRef bead arrays) looking for possible mechanisms and new candidates contributing to the effects of a single dose of MDMA (15 mg/kg) 3 weeks earlier or venlafaxine (40 mg/kg) administration for 3 weeks continously. We also examined the possible interaction between the single dose MDMA treatment and the continous venlafaxine treatment described above.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL17223

46 Samples

Download data: TXT

(Submitter supplied) Vitamin D is an important calcium-regulating hormone with diverse functions in numerous tissues including the brain. Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function and that vitamin D deficiency may accelerate age-related cognitive decline. Using aging rodents, we attempted to model the range of human serum vitamin D levels, from deficient to sufficient, to test whether vitamin D could preserve or improve cognitive function with aging. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5345

Platform:

GPL6247

26 Samples

Download data: CEL

Analysis of hippocampus from F344 rats fed dietary supplement of cholecalciferol (vitamin D3) at doses of 10,000, 1000 and 100 IU/kg diet for 18 weeks. Results provide insight into molecular mechanisms underlying vitamin D-mediated synaptic function enhancement.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 dose sets

Platform:

GPL6247

Series:

GSE61326

26 Samples

Download data: CEL

(Submitter supplied) The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament and environmental reactivity. We selectively bred rats for high versus low behavioral response to novelty and found that high-reactive (bred high-responder, bHR) rats displayed greater risk-taking, impulsivity and aggression relative to low-reactive (bred low-responder, bLR) rats, which showed high levels of anxiety/depression-like behavior and certain stress vulnerability. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL19519

160 Samples

Download data: PAIR