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Links from GEO DataSets

Items: 10

1.
Full record GDS4506

Liver response to obesity and fasting

Analysis of liver endoplasmic reticulum (ER)-associated polysomes from leptin deficient (ob/ob) males after overnight fasting. The liver is critical for metabolic homeostasis. Results provide insight into molecular mechanisms underlying changes in protein metabolism caused by obesity and diabetes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 protocol sets
Platform:
GPL1261
Series:
GSE39375
10 Samples
Download data: CEL, CHP
2.

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting

(Submitter supplied) Obesity-associated metabolic complications are generally considered to emerge from abnormalities in carbohydrate and lipid metabolism, whereas the status of protein metabolism is not well studied. Here, we performed comparative polysome and associated transcriptional profiling analyses to study the dynamics and functional implications of endoplasmic reticulum (ER)-associated protein synthesis in the mouse liver under conditions of obesity and nutrient deprivation.
Organism:
Mus musculus
Type:
Expression profiling by array; Other
Dataset:
GDS4506
Platform:
GPL1261
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE39375
ID:
200039375
3.

Changes in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice

(Submitter supplied) We examined the effect of oral TUDCA treatment on hepatic steatosis and associated changes in hepatic gene expression in ob/ob mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE22608
ID:
200022608
4.

The effect of CLA diet on liver gene expression

(Submitter supplied) apoE-deficient mice were fed a Western-type diet enriched with linoleic acid (control), cis-9, trans-11-CLA or trans-10, cis-12-CLA (1.0 % wt/wt) for 12 weeks and their hepatic gene expression was analysed using DNA microarrays Keywords: influence of diet
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
3 Samples
Download data: CEL
Series
Accession:
GSE7076
ID:
200007076
5.

Liver transcriptome comparison of divergently selected Lean and Fat mouse lines in cholesterol homeostasis, bile acids, glucose and lipoprotein metabolism

(Submitter supplied) This study aimed to identify molecular basis of obesity-resistant mechanisms in the Lean line with the emphasis on lipid homeostasis. Expression profiling using custom Steroltalk v2 microarray demonstrated that Lean mice exhibit a higher hepatic expression of cholesterol synthesis genes compared to the Fat line. A significant difference between the strains was also found in the bile acid metabolism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7190
17 Samples
Download data: TXT
Series
Accession:
GSE24967
ID:
200024967
6.

Liver gene expression profile _ wild type_ CYP7A1 transgenic

(Submitter supplied) Bile acids are not only physiological detergents facilitating nutrient absorption, but also signaling molecules regulating metabolic homeostasis. We reported recently that transgenic expression of CYP7A1 in mice stimulated bile acid synthesis and prevented Western diet-induced obesity, insulin resistance and hepatic steatosis. The aim of this experiment is to determine the impact of induction of hepatic bile acid synthesis on liver metabolism by determining hepatic gene expression profile in CYP7A1 transgenic mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: TXT
Series
Accession:
GSE38872
ID:
200038872
7.

Effect of GW4064 on primary cultured mouse kidney proximal tubule cells

(Submitter supplied) Global gene expression in primary cultured mouse kidney proximal tubule cells treated with either DMSO or 1uM GW4064 (an FXR agonist) was compared. Results provide insight into mechanisms underlying effects of FXR activation on gene expression in mouse kidney proximal tubule cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
8 Samples
Download data: TXT
Series
Accession:
GSE70296
ID:
200070296
8.

Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities, but not Inflammation and Injury in Mice

(Submitter supplied) Abnormalities in hepatic lipid metabolism are believed to play a critical role in the etiology of nonalcoholic steatohepatitis (NASH). Monoacylglycerol acyltransferase (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol (TAG) synthesis. Hepatic expression of Mogat1, which encodes an MGAT enzyme, is increased in the livers of mice with hepatic steatosis and knocking down Mogat1 improves insulin sensitivity, but whether increased MGAT activity plays a role in the etiology of NASH is unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5425
Platform:
GPL6887
8 Samples
Download data: TXT
Series
Accession:
GSE60349
ID:
200060349
9.
Full record GDS5425

Monoacylglycerol acyltransferase 1 deficiency effect on high-fat diet fed mice: liver

Analysis of liver from diet-induced obese males depleted for monoacylglycerol acyltransferase 1 (Mogat1) via intraperitoneal injections of antisense oligonucleotide directed against Mogat1. Results provide insight into the role of Mogat1 in the development of nonalcoholic steatohepatitis (NASH).
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6887
Series:
GSE60349
8 Samples
Download data
10.

Expression data from NSC11, 0923, and GBMJ1 polysome-bound RNA and total RNA

(Submitter supplied) Defining radioresponse using the translatome and the transcriptome to identify functional consequences of radiation. We used microarrays to detail the changes in glioblastoma stem-like cells (GSCs) in both the translatome and transcriptome after irradiation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
54 Samples
Download data: CEL, CHP
Series
Accession:
GSE74084
ID:
200074084
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