Similar studies for GEO DataSets (Select 4497) - GEO DataSets

Select item 44971.

Acute myeloid leukemia cell lines with high Ecotropic Viral Integration site 1 expression

Analysis of acute myeloid leukemia (AML) cell lines with high or low Ecotropic viral integration site 1 (EVI1) expression. High EVI1 levels predict adverse outcome in chemotherapy-resistant AML patients. Results provide insight into novel molecular targets in AML with high EVI1 expression.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 12 cell line, 3 disease state, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE35159
12 Samples

Download data: CEL

DataSet

Accession:: GDS4497

ID:: 4497

Select item 2000351592.

The expression profiles of AML cell lines

(Submitter supplied) EVI1 is one of the famous poor prognostic markers for a chemotherapy-resistant acute myeloid leukemia (AML). To identify molecular targets on the surface of leukemia cells with EVI1high expression, we compared the gene expression profiles of several AML cell lines by DNA microarray

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4497
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE35159

ID:: 200035159

Select item 2001954973.

EVI1 drives leukemogenesis through aberrant activation of ERG

(Submitter supplied) Chromosomal rearrangements involving EVI1 (MECOM) define a subtype of acute myeloid leukemia (AML) that is associated with a two-year survival rate of <10%. Gene regulatory functions of EVI1 are largely elusive and no targeted therapeutics exist. We developed experimentally tractable murine and human leukemia models that recapitulate phenotypic and transcriptional features of EVI1-rearranged AML and enable large-scale loss-of-function screens. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
38 Samples

Download data: BIGWIG, TXT

Series

Accession:: GSE195497

ID:: 200195497

PubMed Similar studies

Select item 2000861514.

Targeting the Creatine Kinase Pathway in EVI1-Positive Acute Myeloid Leukemia

(Submitter supplied) Purpose: Identify new targets in EVI1-Positive Acute Myeloid Leukemia Methods: Treatment with cyclocreatine of EVI1-driven AML cell lines TF-1, UT-7 and UCSD-AML1. Cyclocreatine was purchased from Sigma-Aldrich (Sigma). TF-1, UT-7 and UCSD-AML1 cells were treated in quadruplicate with either vehicle or 3 mM cyclocreatine for 24 hours. Total RNA was extracted and profiled by RNA sequencing (HiSeq, Illumina) at BioMicroCenter from Massachusetts Institute of Technology (Cambridge, MA, USA). more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: TXT

Series

Accession:: GSE86151

ID:: 200086151

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000666605.

Gene expression changes in U937 cells in response to ectopic expression of EVI1 and/or etoposide treatment

(Submitter supplied) Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid cell line constitutively overexpressing EVI1 after infection with a retroviral vector (U937_EVI1) was partially resistant to etoposide and daunorubicin as compared to empty vector infected control cells (U937_vec). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5809
Platform:: GPL11532
8 Samples

Download data: CEL

Series

Accession:: GSE66660

ID:: 200066660

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 58096.

Anti-leukemia drug etoposide effect on ecotropic viral integration site 1-overexpressing myeloid cells

Analysis of myeloid cell line U937 overexpressing ecotropic viral integration site 1 (EVI1) and cultured in the presence of antileukemic drug etoposide. Results provide insight into molecular mechanisms through which EVI1 confers resistance to drugs used in myeloid leukemia therapy.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 protocol sets

Platform:: GPL11532
Series:: GSE66660
8 Samples

Download data: CEL

DataSet

Accession:: GDS5809

ID:: 5809

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000391037.

Gene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [EVI1_ST]

(Submitter supplied) The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive response of primary murine hematopoietic cells to the transcriptional upregulation of Evi1, we developed an inducible lentiviral vector system with a robust expression switch. more...