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Links from GEO DataSets

Items: 7

1.
Full record GDS4449

Model of β-catenin overexpression in embryonic kidney

Analysis of β-catGOF-UB (β-catenin Gain of Function-Ureteric Bud) mutant kidneys from E12.5 embryos. The β-catGOF-UB mutants display severe renal malformations. Results provide insight into the role of β-catenin in renal dysplasia.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE20325
6 Samples
Download data: CEL, CHP
2.

Stabilization of ß-catenin during murine Kidney Development

(Submitter supplied) We define a pathogenic role for a ß-catenin-activated genetic pathway in murine renal dysplasia. Cre-mediated stabilization of ß-catenin in the ureteric cell lineage prior to the onset of kidney development increased ß-catenin levels and caused renal aplasia or severe hypodysplasia. A genome-wide analysis of mRNA expression in dysplastic tissue identified down-regulation of genes required for ureteric branching and up regulation of Tgfß2 and Dkk1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4449
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE20325
ID:
200020325
3.

Comparison of normal and beta catenin deficient kidney gene expression profiles at E12.5

(Submitter supplied) We generated a murine genetic model of beta-catenin deficiency targeted to the ureteric bud cell lineage to study the role of beta-catenin mediated Wnt signaling during ureteric morphogenesis. Keywords: mutation
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3322
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE9629
ID:
200009629
4.
Full record GDS3322

Beta-catenin deficiency model: kidney

Analysis of embryonic (E12.5) kidneys with beta-catenin deficiency targeted to the ureteric bud cell lineage. Inactivation of beta-catenin leads to abnormal ureteric branching and causes renal aplasia or dysplasia. Results provide insight into the role of beta-catenin during ureteric morphogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE9629
6 Samples
Download data: CEL
DataSet
Accession:
GDS3322
ID:
3322
5.

Beta-catenin/GFP

(Submitter supplied) 293 cells, infected with RCAS-beta-cateninS37A or RCAS-GFP Keywords = 293cells Keywords = beta catenin Keywords: repeat sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS748
Platform:
GPL96
8 Samples
Download data
Series
Accession:
GSE1473
ID:
200001473
6.
Full record GDS748

Beta-catenin S37A mutant effect on gene expression

Expression profiling of 293T cells infected with RCAS vector carrying beta-catenin S37A mutant. Beta-catenin S37A mutant is oncogenic and more stable than the corresponding wild type protein.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell line sets
Platform:
GPL96
Series:
GSE1473
8 Samples
Download data
7.

Mouse embryonic kidneys (E13.5): mutant (UB HDAC1,2-/-) vs. wild type

(Submitter supplied) Transcriptional profiling of mouse embryonic kidneys (E13.5) comparing UB HDAC1,2-/- kidneys with wild type kidneys. Studies in our lab showed that histone deacetylase 1 (HDAC1) and 2 (HDAC2) perform redundant, yet essential functions in the developing mouse ureteric bud (UB) tissue. Double deletion of HDAC1 and HDAC2 in the UB results in impaired UB branching morphogenesis, followed by severe kidney dysgenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
8 Samples
Download data: TXT
Series
Accession:
GSE35432
ID:
200035432
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Supplemental Content

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