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Links from GEO DataSets

Items: 8

1.
Full record GDS4434

Tuberous sclerosis complex 1 deficient CD4 T cell response to T cell receptor stimulation

Analysis of Tuberous sclerosis complex 1 (Tsc1) deficient CD4 T cells after T cell receptor stimulation using anti-CD3-CD28. Tsc1 is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results provide insight into the role of Tsc1 in T cell quiescence.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL11180
Series:
GSE29797
12 Samples
Download data: CEL
2.

Tuberous sclerosis complex 1 (Tsc1) enforces quiescence of naive T cells to promote immune homeostasis and function

(Submitter supplied) The mechanisms that regulate T cell quiescence are poorly understood. We report that tuberous sclerosis complex 1 (Tsc1) establishes a quiescent program in naïve T cells by controlling cell size, cell cycle entry, and responses to T cell receptor stimulation. Loss of quiescence predisposed Tsc1-deficient T cells to apoptosis that depleted conventional T cells and invariant natural killer T cells. Loss of Tsc1 function dampened in vivo immune responses to bacterial infection. Tsc1-deficient T cells exhibited increased mTORC1 but diminished mTORC2 activities, with mTORC1 activation essential for the disruption of immune homeostasis. Therefore, Tsc1-dependent control of mTOR is crucial in establishing naïve T cell quiescence to facilitate adaptive immune function.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4434 GDS4572
Platform:
GPL11180
16 Samples
Download data: CEL
Series
Accession:
GSE29797
ID:
200029797
3.
Full record GDS4572

Tuberous sclerosis complex 1 deficient naïve CD4 and CD8 T cells

Analysis of naïve CD4 and CD8 T cells deficient for Tuberous sclerosis complex 1 (Tsc1). Tsc1 tumor suppressor is an mTOR signaling modulator involved in naive T cell quiescence and immune homeostasis regulation. Results identify a Tsc1-dependent gene signature in naive T cells.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 cell type, 2 genotype/variation sets
Platform:
GPL11180
Series:
GSE29797
10 Samples
Download data: CEL
4.

Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs

(Submitter supplied) Memory CD8+ T cells are an essential component of protective immunity. Signaling via mechanistic target of rapamycin (mTOR) has been implicated in the regulation of the differentiation of effector and memory T cells. However, little is understood about the mechanisms that control mTOR activity, or the effector pathways regulated by mTOR, in this process. We describe here that tuberous sclerosis 1 (Tsc1), a regulator of mTOR signaling, plays a crucial role in promoting the differentiation and function of memory CD8+ T cells in response to Listeria monocytogenes infection. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
9 Samples
Download data: CEL
Series
Accession:
GSE61591
ID:
200061591
5.

mTORC1 couples immune signals and metabolic programming to establish Treg cell function

(Submitter supplied) The mechanistic target of rapamycin (mTOR) pathway integrates diverse environmental inputs, including immune signals and metabolic cues, to direct T cell fate decisions1. Activation of mTOR, comprised of mTORC1 and mTORC2 complexes, delivers an obligatory signal for proper activation and differentiation of effector CD4+ T cells2,3, whereas in the regulatory T cell (Treg) compartment, the Akt-mTOR axis is widely acknowledged as a crucial negative regulator of Treg de novo differentiation4-8 and population expansion9. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
8 Samples
Download data: CEL
Series
Accession:
GSE46693
ID:
200046693
6.

Gene expression profiles of Lkb1 WT and KO hematopoietic stem cells (HSCs)

(Submitter supplied) LKB1 encodes a Ser/Thr kinase and acts as an evolutionarily conserved sensor of cellular energy status in eukaryotic cells. LKB1 functions as the major upstream kinase to phosphorylate AMPK and 12 other AMPK-related kinases, which is required for their activation in many cellular contexts. Once activated, AMPK and AMPK-related kinases phosphorylate a diverse array of downstream effectors to switch on ATP-generating catabolic processes and switch off ATP-consuming anabolic processes, thus restoring energy balance during periods of energetic stress. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
7 Samples
Download data: CEL
Series
Accession:
GSE24765
ID:
200024765
7.

Raptor/mTORC1-dependent metabolic programming of exit from quiescence underlies T cell activation and fate decisions

(Submitter supplied) Naïve T cells respond to antigen stimulation by exiting from quiescence into clonal expansion and functional differentiation, but the control mechanism is elusive. Here we describe that Raptor/mTORC1-dependent metabolic reprogramming is a central determinant of this transitional process. Loss of Raptor abrogates T cell priming and Th2 cell differentiation, although Raptor function is less important for continuous proliferation of actively cycling cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
24 Samples
Download data: CEL
Series
Accession:
GSE51668
ID:
200051668
8.

Rapamycin-insensitive up-regulation of MMP2 and other genes in TSC2- deficient LAM-like cells

(Submitter supplied) Rationale: Increased matrix metalloproteinase (MMP) activity has been implicated in the pathogenesis of lymphangioleiomyomatosis (LAM). Objectives: To investigate how TSC1 or TSC2 deficiency alters MMP expression and regulation. Methods: We studied immortalized cells that lack TSC2 derived from an angiomyolipoma (AML) of a LAM patient, and a TSC2 add back derivative; and murine embryonic fibroblast cells that lack Tsc1 or Tsc2 and respective controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2895
9 Samples
Download data
Series
Accession:
GSE16944
ID:
200016944
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