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Links from GEO DataSets

Items: 8

1.
Full record GDS4396

Unresectable colorectal cancer primary or metastatic lesions: test set

Analysis of primary or metastatic lesions from patients with unresectable colorectal cancer (CRC) prior to FOLFOX6 therapy (oxaliplatin, 5-fluorouracil, leucovorin regimen). Results provide insight into molecular signatures that predict responders to FOLFOX therapy for unresectable CRC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 individual, 2 specimen sets
Platform:
GPL570
Series:
GSE28702
29 Samples
Download data: CEL
2.

CRC samples for FOLFOX therapy prediction

(Submitter supplied) The aim of this study is to identify responders to FOLFOX therapy by applying the Random Forests (RF) algorithm to gene expression data. Eighty-three unresectable colorectal cancer (CRC) patients including 42 responders and 41 non-responders were divided into training (54 patients) and test (29 patients) sets.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4393 GDS4396
Platform:
GPL570
83 Samples
Download data: CEL
Series
Accession:
GSE28702
ID:
200028702
3.
Full record GDS4393

Unresectable colorectal cancer primary or metastatic lesions: training set

Analysis of primary or metastatic lesions from patients with unresectable colorectal cancer (CRC) prior to FOLFOX6 therapy (oxaliplatin, 5-fluorouracil, leucovorin regimen). Results provide insight into molecular signatures that predict responders to FOLFOX therapy for unresectable CRC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 individual, 2 specimen sets
Platform:
GPL570
Series:
GSE28702
54 Samples
Download data: CEL
4.

Gene expression signature and the prediction of liver metastasis in colorectal cancer by DNA microarray

(Submitter supplied) Samples were taken from colorectal cancers in surgically resected specimens in 189 colorectal cancer patients. The expression profiles were determined using Affymetrix Human Genome U133 Plus 2.0 arrays. Comparison between the sample groups allow to identify a set of discriminating genes that can be used for molecular markers for predicting liver metastasis. Keywords: repeat
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
189 Samples
Download data
Series
Accession:
GSE14095
ID:
200014095
5.

Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL97 GPL96
114 Samples
Download data: CEL
Series
Accession:
GSE62322
ID:
200062322
6.

Specific extracellular matrix remodeling signature of colon hepatic metastases [HG-U133B]

(Submitter supplied) To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL97
57 Samples
Download data: CEL
Series
Accession:
GSE62321
ID:
200062321
7.

Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan

(Submitter supplied) In patients with advanced colorectal cancer, leucovorin, fluorouracil, and irinotecan (FOLFIRI) is considered as one of the reference first-line treatments. However, only about half of treated patients respond to this regimen, and there is no clinically useful marker that predicts response. A major clinical challenge is to identify the subset of patients who could benefit from this chemotherapy. We aimed to identify a gene expression profile in primary colon cancer tissue that could predict chemotherapy response. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
21 Samples
Download data: CEL
Series
Accession:
GSE62080
ID:
200062080
8.

Specific extracellular matrix remodeling signature of colon hepatic metastases [HG-U133A]

(Submitter supplied) To identify genes implicated in metastatic colonization of the liver in colorectal cancer, we collected pairs of primary tumors and hepatic metastases before chemotherapy in 13 patients. We compared mRNA expression in the pairs of patients to identify genes deregulated during metastatic evolution. We then validated the identified genes using data obtained by different groups. The 33-gene signature was able to classify 87% of hepatic metastases, 98% of primary tumors, 97% of normal colon mucosa, and 95% of normal liver tissues in six datasets obtained using five different microarray platforms. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
57 Samples
Download data: CEL
Series
Accession:
GSE49355
ID:
200049355
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