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Links from GEO DataSets

Items: 8

1.
Full record GDS4394

Niemann-Pick Type C disease brain: time course

Analysis of brain across 6 age groups of Npc1−/− Balb/c females with Niemann-Pick Type C (NPC) disease. NPC is a neurodegenerative, lysosomal disorder caused by Npc1 or Npc2 gene dysfunction. Results provide insight into the molecular mechanisms underlying NPC progression.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 13 age, 3 genotype/variation sets
Platform:
GPL1261
Series:
GSE39621
27 Samples
Download data: CEL
2.

Expression data from brain, liver and spleen of Npc1-/- mice

(Submitter supplied) Niemann-Pick Type C (NPC) disease is a rare, genetic, lysosomal disorder with progressive neurodegeneration. Poor understanding of the pathophysiology and lack of blood-based diagnostic markers are major hurdles in the treatment and management of NPC and several additional neurological, lysosomal disorders. To identify disease severity correlates, we undertook whole genome expression profiling of sentinel organs, brain, liver, and spleen of Balb/c Npc1-/- mice (Npc1nih)relative to Npc1+/- at an asymptomatic stage, as well as early- and late-symptomatic stages. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4394 GDS4427 GDS4428
Platform:
GPL1261
51 Samples
Download data: CEL, TXT
Series
Accession:
GSE39621
ID:
200039621
3.
Full record GDS4428

Niemann-Pick Type C disease spleen: time course

Analysis of spleen across 3 age groups of Npc1−/− Balb/c females with Niemann-Pick Type C (NPC) disease. NPC is a neurodegenerative, lysosomal disorder caused by Npc1 or Npc2 gene dysfunction. Results provide insight into the molecular mechanisms underlying NPC progression.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 6 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE39621
12 Samples
Download data: CEL
4.
Full record GDS4427

Niemann-Pick Type C disease liver: time course

Analysis of liver across 3 age groups of Npc1−/− Balb/c females with Niemann-Pick Type C (NPC) disease. NPC is a neurodegenerative, lysosomal disorder caused by Npc1 or Npc2 gene dysfunction. Results provide insight into the molecular mechanisms underlying NPC progression.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 6 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE39621
12 Samples
Download data: CEL
5.

Expression data from liver tissue from Npc1 mouse model

(Submitter supplied) We used microarrays to detail the global programme of gene expression underlying the disease progression in the mutant mice compared to their control littermates.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
78 Samples
Download data: CEL
Series
Accession:
GSE33467
ID:
200033467
6.

Global gene expression change in the cerebellum of Niemann-Pick disease type C mice with deletion of Ccl3 or Purkinje neuron-specific NPC1 rescue

(Submitter supplied) Macrophage inflammatory protein 1alpha/CCL3 protein is a known pro-inflammatory cytokine that can mediate chemotaxis of monocytes and promote cell degranulation. Ccl3 gene expression is elevated in the CNS and visceral tissue of many lysosomal storage disorders. The deletion of Ccl3 in a mouse model of Sandhoff disease was reported to result in reduced monocyte-associated pathology in the brain, delayed neurodegeneration, and prolonged health. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE36119
ID:
200036119
7.

Microarray analysis in Npc1-/- mouse cerebellum

(Submitter supplied) Niemann-Pick Type C disease is an autosomal recessive neurodegenerative disorder with abnormal lipid storage as the major cellular pathologic hallmark. Genetic analyses have identified mutations in NPC1 gene in the great majority of cases, while mutations in NPC2 account for the remainders. Yet, little is known regarding the cellular mechanisms responsible for NPC pathogenesis, especially for neurodegeneration, which is the usual cause of death. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL4134 GPL6481
16 Samples
Download data: TXT
Series
Accession:
GSE20450
ID:
200020450
8.

Aging Experiment

(Submitter supplied) Lifelong murine gene expression profiles in relation to chronological and biological aging in multiple organs
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14996
90 Samples
Download data: CEL
Series
Accession:
GSE34378
ID:
200034378
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