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Links from GEO DataSets

Items: 9

1.
Full record GDS4374

Entamoeba histolytica infected sigmoid colon

Analysis of colon biopsies from individuals during acute E. histolytica diarrhea (day 1) versus convalescence (day 60) post metronidazole treatment. The E. histolytica pathogen causes diarrhea and colitis. Results provide insight into the molecular mechanisms underlying amebic colitis pathology.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 time sets
Platform:
GPL6244
Series:
GSE23750
16 Samples
Download data: CEL, CHP
2.

Role of REG 1 in Entamoeba histolytica colitis

(Submitter supplied) Differential expression was used to access gene differences after Entamoeba histolytica infection. Entamoeba histolytica is an important diarrheal pathogen worldwide, and induces apoptosis of the intestinal epithelium as part of its disease process. Regenerating (REG) 1 protein is anti-apoptotic. We investigated the involvement of REG 1 in E. histolytica colitis. Colonic biopsy samples were obtained from 8 subjects with acute E. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4374
Platform:
GPL6244
16 Samples
Download data: CEL, CHP
Series
Accession:
GSE23750
ID:
200023750
3.

Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome.

(Submitter supplied) A genome-wide transcriptional analysis of Entamoeba histolytica was performed on trophozoites isolated from the colon of six infected mice and from in vitro culture. Adaptation to the intestinal environment was accompanied by increases in a subset of cell signaling genes including transmembrane kinases, ras and rho family GTPases, and calcium binding proteins. Significant decreases in mRNA abundance for genes involved in glycolysis and concomitant increases in lipases were consistent with a change in energy metabolism. more...
Organism:
Entamoeba histolytica
Type:
Expression profiling by array
Platform:
GPL4622
7 Samples
Download data: CEL
Series
Accession:
GSE8484
ID:
200008484
4.

Entamoeba histolytica E_his-1a520285F array (coding regions)

(Submitter supplied) A custom generated Affymetrix platform full genome microarray (E_his-1a520285F). This array has 7,712 unique probe sets representing 9,435 open reading frames (ORFs). Due to the highly repetitive nature of the E. histolytica genome, some of the probe sets are predicted to cross-hybridize with other sequences. Probe sets that represent a single gene are labeled as (_at). Probe sets in which at least one probe may cross-hybridize with another gene(s) are labeled as (_x_at). more...
Organism:
Entamoeba histolytica
10 Series
67 Samples
Download data: CDF
Platform
Accession:
GPL4622
ID:
100004622
5.

Characterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection

(Submitter supplied) The unicellular eukaryote Entamoeba histolytica is a human parasite that causes amebic dysentery and liver abscess. A genome-wide analysis of gene expression modulated by intestinal colonization and invasion identified an up-regulated transcript that encoded a putative high-mobility-group box (HMGB) protein, EhHMGB1. We tested if EhHMGB1 encoded a functional HMGB protein, and determined its role in control of parasite gene expression. more...
Organism:
Entamoeba histolytica
Type:
Expression profiling by array
Platform:
GPL4622
6 Samples
Download data: CEL
Series
Accession:
GSE12204
ID:
200012204
6.

Virulent and nonvirulent Entamoeba species comparison

(Submitter supplied) Entamoeba histolytica is a protozoan parasite that causes colitis and liver abscesses. Several Entamoeba species and strains with differing levels of virulence have been identified. E. histolytica HM-1:IMSS is a virulent strain, E. histolytica Rahman is a nonvirulent strain, and Entamoeba dispar is a nonvirulent species. We used an E. histolytica DNA microarray consisting of 2,110 genes to assess the transcriptional differences between these species/strains with the goal of identifying genes whose expression correlated with a virulence phenotype. more...
Organism:
Entamoeba histolytica
Type:
Expression profiling by array
Dataset:
GDS1825
Platform:
GPL2662
12 Samples
Download data
Series
Accession:
GSE4139
ID:
200004139
7.
Full record GDS1825

Virulent and non-virulent Entamoeba species comparison

Expression profiling of virulent and non-virulent Entamoeba strains and species. Entamoeba histolytica is a protozoan parasite that causes colitis and liver abscesses. Results identify expression patterns indicative of a virulence phenotype.
Organism:
Entamoeba histolytica
Type:
Expression profiling by array, log2 ratio, 2 other, 2 species, 3 strain sets
Platform:
GPL2662
Series:
GSE4139
12 Samples
Download data
8.

Gene expression in Entamoeba histolytica cysts and trophozoites

(Submitter supplied) We compared multiple strains of lab trophozoites to recent clinical isolates. Clinical isolates were grown in xenic media, and maintained many characteristics of the cyst stage of devlopment Keywords: Stage conversion
Organism:
Entamoeba histolytica
Type:
Expression profiling by array
Platform:
GPL4622
19 Samples
Download data: CEL
Series
Accession:
GSE6648
ID:
200006648
9.

The Effect of the Leptin Receptor Q223R Polymorphism on the Host Transcriptome Following Infection with E. histolytica.

(Submitter supplied) Resistance to amebiasis is associated with a polymorphism in the leptin receptor. Previous studies demonstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likely to be infected with Entamoeba histolytica than those carrying the mutant R223 allele. We hypothesized that the Q223 allele protected against E. histolytica via STAT3-mediated transcription of genes required for mucosal immunity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
54 Samples
Download data: CEL, CHP
Series
Accession:
GSE43372
ID:
200043372
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