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Links from GEO DataSets

Items: 17

1.
Full record GDS4373

Activated Autoimmune Regulator (AIRE)-deficient, CD8+CD28low regulatory T lymphocytes

Analysis of AIRE-deficient, CD8+CD28low regulatory T (Treg) cells stimulated with allogeneic antigen-presenting cells (APC) and anti-CD3 antibody. Results provide insight into the role of AIRE in the function of regulatory T-cell populations, which are central to the prevention of immunopathology.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL6246
Series:
GSE30129
12 Samples
Download data: CEL
2.

AIRE-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis

(Submitter supplied) Mutations in the gene encoding the transcription factor AutoImmune REgulator (AIRE) are responsible for the ‘Autoimmune PolyEndocrinopathy Candidiasis Ecodermal Dystrophy’ syndrome. AIRE directs expression of tissue restricted antigens in the thymic medulla and in lymph node stromal cells and thereby substantially contributes to induction of immunological tolerance to self-antigens. Data from experimental mouse models showed that AIRE-deficiency leads to impaired deletion of autospecific T cell precursors. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4373
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE30129
ID:
200030129
3.

Expression data from WT and Aire deficient mTECs

(Submitter supplied) Aire is an important transcription regulator that mediates a role in central tolerance via promoting the promiscuous expression of tissue-specific antigens in the thymus. Although several mouse models of Aire-deficiency have been described, none has analysed the phenotype induced by a mutation that emulates the common 13bp deletion in human APECED by disrupting the first PHD domain in exon 8. Aire-deficient mice with a corresponding mutation showed some disturbance of the medullary epithelial compartment, but at the phenotypic level their T cell compartment appeared relatively normal in the thymus and periphery. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
5 Samples
Download data: CEL
Series
Accession:
GSE14365
ID:
200014365
4.

wild type and aire -/- murine meduallary thymic epithelial cells

(Submitter supplied) Mice used were B6/129 F2's, 3-5 weeks of age, either wild type or with both copies of the autoimmune regulator gene (aire, GenBank #AF079536) disrupted. Thymi from five of these mice of both sexes were removed and pooled. After collagenase/dispase digestion, density gradient fractionation, and fluorescent antibody staining, cells with the phenotype CD45-, G8.8+, CDR1int and B7.1hi were FACS-sorted and total RNA was made from them. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS167
Platform:
GPL81
6 Samples
Download data: CEL
Series
Accession:
GSE85
ID:
200000085
5.
Full record GDS167

Autoimmune disease mechanisms

Examination of medullary thymic epithelial cells from aire-deficient mice. aire is autoimmune regulator gene. Aim to understand autoimmune disease mechanisms, esp. autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED).
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL81
Series:
GSE85
6 Samples
Download data: CEL
DataSet
Accession:
GDS167
ID:
167
6.

Aire regulates transfer of antigen from mTEC to dendritic cells for induction of thymic tolerance

(Submitter supplied) To investigate the role of Aire in thymic selection, we examined the cellular requirements for generation of ovalbumin (OVA)-specific CD4 and CD8 T cells in mice expressing OVA under the control of the rat insulin promoter (RIP). Aire-deficiency reduced the number of mature single positive (SP) OVA-specific CD4+ or CD8+ T cells in the thymus, independent of OVA expression. Importantly, it also contributed in two way to OVA-dependent negative selection depending on the T cell type. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6481
6 Samples
Download data: TXT
Series
Accession:
GSE28393
ID:
200028393
7.

Gene expression profiling of perinatal or adult medullary thymic epithelial cells (MECs)

(Submitter supplied) A comparative analysis of gene expression of perinate or adult Aire-GFP+ and GFP- MECs in WT or Aire-KO thymus
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
17 Samples
Download data: CEL
Series
Accession:
GSE66402
ID:
200066402
8.

Gene expression profiling of perinatal or adult regulatory T cells (Tregs)

(Submitter supplied) A comparative analysis of gene expression of 3 different experiments; 1. Perinate or adult-tagged GFP+YFP+ and bulk GFP+YFP- Tregs, 2. FL or BM-derived Tregs 3. Perinate or adult thymic Tregs.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE66332
ID:
200066332
9.

Analysis of Aire effects on individual mice of different genetic backgrounds

(Submitter supplied) We compared gene expression profiles of aire-deficient and wild-type littermate thymic medullary epithelial cells. This was done in order to determine whether Aire's effects differed among strains, and also among individuals of the same strain. Keywords: genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
20 Samples
Download data: CEL
Series
Accession:
GSE8564
ID:
200008564
10.

Aire co-opts the repressive ATF7ip/MBD1 protein complex for the induction of immune tolerance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6244 GPL7202
15 Samples
Download data: CEL, TXT
Series
Accession:
GSE52548
ID:
200052548
11.

Medullary Thymic Epitherlial Cell (mTEC) Gene Expression in MBD1 WT and KO Mice

(Submitter supplied) To explore global gene expression using microarray analysis in mTEC's isolated from MBD1 WT and MBD1 KO mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
6 Samples
Download data: TXT
Series
Accession:
GSE52547
ID:
200052547
12.

Gene expression of HEK 293 cells transfected with Vector (PCMV), Aire, or MBD-VP16

(Submitter supplied) HEK 293 cells were transiently transfected with plasmids expressing Vector only(PCMV), Aire, or MBD-VP16 with the goal of comparing the global gene expression profiles in the Aire and MBD-VP16 groups We used microarrays to detail the global gene expression profile.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL, TXT
Series
Accession:
GSE52546
ID:
200052546
13.

Genome-wide analysis of the TEC-specific Hipk2 gene knockout in mouse medullary thymic epithelial cells (mTECs)

(Submitter supplied) Analysis of the role of Hipk2 in regulating gene expression in medullary thymic epithelial cells. The whole genome gene signatures of purified mTEC subsets (CD80 low, CD80 high) from TEC-specific Hipk2 knockout mice were compared to mating wildtype control mice (floxed, Cre-). Results provide the up- or down-regulated genes, affected by the Hipk2 gene knockout.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17543
8 Samples
Download data: IDAT, TXT
Series
Accession:
GSE63432
ID:
200063432
14.

Aire, guardian of immunological tolerance, binds to and activates super-enhancers

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
4 related Platforms
51 Samples
Download data: BIGWIG, CEL
Series
Accession:
GSE92654
ID:
200092654
15.

Aire, guardian of immunological tolerance, binds to and activates super-enhancers [ChIP-seq]

(Submitter supplied) ChIP-seq profile of Aire and partners in MECs
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL16417 GPL17021
23 Samples
Download data: BIGWIG
Series
Accession:
GSE92597
ID:
200092597
16.

Aire, guardian of immunological tolerance, binds to and activates super-enhancers [ATAC-seq]

(Submitter supplied) ATAC-seq profiles of MECs and earskin fibroblasts
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: BIGWIG
Series
Accession:
GSE92594
ID:
200092594
17.

Aire, guardian of immunological tolerance, binds to and activates super-enhancers [expression]

(Submitter supplied) Microarray profiles of MECs from mice treated with topoisomerase inhibitors
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
22 Samples
Download data: CEL
Series
Accession:
GSE92509
ID:
200092509
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