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Links from GEO DataSets

Items: 7

1.
Full record GDS4368

DSS-induced colitis model response to L-arginine supplementation

Analysis of colon from dextran sulfate sodium (DSS)-treated C57BL/6 males following L-arginine supplementation. L-Arg supplementation improves clinical parameters of DSS-induced colitis. Results provide insight into molecular mechanisms underlying the clinical benefit of L-Arg supplementation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 disease state sets
Platform:
GPL6246
Series:
GSE34874
12 Samples
Download data: CEL
2.

Expression data from murine colon tissue after exposure to 4% DSS for 6 days DSS followed by 4 days of water or 1% L-arginine

(Submitter supplied) L-Arginine (L-Arg) is the substrate for both inducible nitric oxide synthase and arginase, which are upregulated in human IBD and in mouse colitis models. We have found that L-Arg supplementation enhances wound restitution in vitro, and improves the clinical parameters of weight loss, survival, and colon weight/length, in dextran sulfate sodium (DSS) induced murine colitis. Our aim was to further identify the potential mechanisms underlying the clinical benefit of L-Arg supplementation.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4368
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE34874
ID:
200034874
3.

Colonic gene expression data of acute and chronic dextran sodium sulphate (DSS) colitis mice

(Submitter supplied) The lack of suitable animal models reflecting chronically relapsing inflammation and tissue remodeling have hindered fibrosis research in inflammatory bowel diseases (IBD). This study investigated changes in connective tissue in a chronic murine model using different cycles of dextran sodium sulphate (DSS) to mimic the relapsing nature of the disease. We used whole gene expression arrays to study differences in colonic gene expression levels between acute and more chronic DSS colitis,
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
30 Samples
Download data: CEL
Series
Accession:
GSE42768
ID:
200042768
4.

Expression data from mouse colon tissue response to DSS induction at day 0, 2, 4 and 6

(Submitter supplied) Temporal genome profiling of DSS colitis The DSS induced mouse colitis model is often used to emulate Ulcerative Colitis (UC) in order understand pathophysiological mechanism of inflammatory bowel disease (IBD). Given the progressive nature of IBD, colon tissue gene expression changes during the evolution of disease, and knowing the changes in gene expression profiles could indentify potential diagnostic markers or additional therapeutic targets for colitis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3859
Platform:
GPL1261
23 Samples
Download data: CEL, CHP
Series
Accession:
GSE22307
ID:
200022307
5.
Full record GDS3859

Dextran sodium sulfate-induced colitis model: time course

Analysis of colon from C57BL/6J 12-14wk-olds treated with DSS for up to 6 days. DSS model emulates clinical and histopathological features of ulcerative colitis (UC), a type of Inflammatory Bowel Disease (IBD). Results provide insight into molecular mechanisms underlying development of DSS colitis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 disease state, 4 time sets
Platform:
GPL1261
Series:
GSE22307
23 Samples
Download data: CEL, CHP
6.

Next Generation Sequencing Facilitates The Study of the Effect of ABX464 in Intestinal Inflammation

(Submitter supplied) Purpose: The goals of this study are to establish the protective effect of ABX464 in DSS-induced colitis comparing transcript levels between cells (BMDMs) ABX464-treated stimulated or not by LPS. Methods: 24 intestinal macrophages mRNA profiles of three distinct group of BMDM cultures from mice were generated by deep sequencing, using Illumina protocol. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: HISAT and Bowtie2 followed by genes expression quantification using a software package called RSEM. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23479
24 Samples
Download data: TXT
Series
Accession:
GSE97062
ID:
200097062
7.

Comparative expression data between ANGPTL4+/+ and ANGPTL4-/- mice whole colon tissue during DSS or SA-induced inflammation.

(Submitter supplied) Protracted inflammatory responses are signatures common to many gastrointestinal disorders. Severe and chronic disorders often bring about extensive tissue damage, in turn leading to hypercytokinemia. Here, we show that stimuli like dextran sulphate sodium salt (DSS) and stearic acid (SA) cause acute colonic inflammation, and ANGPTL4 is an important regulator in mediating the extent of colonic inflammation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE78500
ID:
200078500
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Supplemental Content

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