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Links from GEO DataSets

Items: 6

1.
Full record GDS4344

Diet-induced model of obesity: mesenteric adipose tissue surrounding pancreas

Analysis of adipose depot surrounding pancreas from cafeteria diet fed Wistar males. In obesity, β-cell mass increases in response to rising insulin demand; this β-cell plasticity is essential to avoid hyperglycemia onset. Results provide insight into molecular basis of β-cell mass adaptation.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 disease state, 2 protocol sets
Platform:
GPL1355
Series:
GSE36935
5 Samples
Download data: CEL
DataSet
Accession:
GDS4344
ID:
4344
2.

Role of IGFBP-3 in the Regulation of β-Cell Mass during Obesity: Adipose Tissue/ β-Cell Cross Talk

(Submitter supplied) In obesity an increase in β-cell mass occurs to cope with the rise in insulin demand. This β -cell plasticity is essential to avoid the onset of hyperglycemia, although the molecular mechanisms that regulate this process remain unclear. This study analyzed the role of adipose tissue in the control of β -cell replication. Using a diet-induced model of obesity, we obtained conditioned media from three different white adipose tissue depots. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4344
Platform:
GPL1355
5 Samples
Download data: CEL
Series
Accession:
GSE36935
ID:
200036935
3.

Gene expression profile in pancreatic islets from control rats fed a standard chow diet and obese rats fed a high-caloric cafeteria diet for 30 days.

(Submitter supplied) Changes in the secretion profile of visceral-pancreatic white adipose tissue (pWAT) due to diet-induced obesity are partially responsible for increased beta cell replication, suggesting that a crosstalk between pWAT and beta cells may play a role in regulating beta cell plasticity. The molecular mechanisms underlying this cross-talk are still not fully understood. The aim of this study was to integrate transcriptomic, proteomic and metabolomic data to unravel the cross-talk between adipose tissue and pancreatic islets during evolution of obesity.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
9 Samples
Download data: CEL
Series
Accession:
GSE44373
ID:
200044373
4.

Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes β-Cell Proliferation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
19 Samples
Download data: CEL
Series
Accession:
GSE44047
ID:
200044047
5.

Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes β-Cell Proliferation [30 days]

(Submitter supplied) Obesity is associated with an increase in β-cell mass in response to the rising demand for insulin. β-cell plasticity is essential to maintaining glucose homeostasis, however, the cellular and molecular mechanisms by which β-cell mass is regulated remain poorly understood. Recently, we described the existence of a crosstalk between the peripancreatic adipose tissue and β-cells as a novel mechanism that participates in the regulation of β-cell plasticity. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
9 Samples
Download data: CEL
Series
Accession:
GSE44046
ID:
200044046
6.

Secreted Frizzled-Related Protein 5 is Downregulated in Obesity and Promotes β-Cell Proliferation [10 days]

(Submitter supplied) Obesity is associated with an increase in β-cell mass in response to the rising demand for insulin. β-cell plasticity is essential to maintaining glucose homeostasis, however, the cellular and molecular mechanisms by which β-cell mass is regulated remain poorly understood. Recently, we described the existence of a crosstalk between the peripancreatic adipose tissue and β-cells as a novel mechanism that participates in the regulation of β-cell plasticity. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
10 Samples
Download data: CEL
Series
Accession:
GSE44045
ID:
200044045
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