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Links from GEO DataSets

Items: 20

1.
Full record GDS4308

Prolonged cardiothoracic surgery effect on diaphragm

Analysis of paired diaphragm biopsies from 5 patients during cardiothoracic surgery: the 1st as soon as diaphragm was exposed, the 2nd as late in surgery as possible (4.9 ± 1.8 hrs between biopsies). Results provide insight into diaphragm muscle biology after prolonged cardiothoracic procedures.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 age, 5 individual, 2 specimen sets
Platform:
GPL570
Series:
GSE19533
10 Samples
Download data: CEL
DataSet
Accession:
GDS4308
ID:
4308
2.

Gene expression changes in the human diaphragm following cardiothoracic surgery

(Submitter supplied) It is unknown how soon the diaphragm begins to start the process of atrophy following the start of MV. We hypothesized that genes responsible for maintaining diaphragmatic contractile function, stress response, energy transduction would be altered over the course of a 5 hour cardiothoracic surgery.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4308
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE19533
ID:
200019533
3.

Retinal gene expression in Egr-1 knock-out mice during development (p30 and p42)

(Submitter supplied) In chicks, the avian homologue of the early growth response protein-1 (ZENK) has been shown to be increased in a special cell type of the retina, the glucagonergic amacrine cells, under conditions that lead to a reduction in eye growth (myopic defocus, recovery of myopia) and decreased under conditions that enhance ocular growth (hyperopic defocus, form-deprivation). The investigation of Egr-1 knock-out mice showed that homozygous knock-out mice with no functional Egr-1 protein developed relative axial myopia at the age of 42 and 56 days, compared to heterozygous- and wildtype Egr-1 knock-out mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3607
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE16974
ID:
200016974
4.
Full record GDS3607

Egr-1 deficiency effect on retina during eye development

Analysis of retinas of Egr-1 deficient animals at post-natal days 30 and 42. 42 day-old Egr-1 knockout animals have longer eyes and a more myopic refractive error compared to wild-types. Results provide insight into the molecular mechanisms regulating axial eye growth.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE16974
16 Samples
Download data: CEL
5.

Comparison of gene expression profile of human trabecular meshwork cells induced by triamcinolone with dexamethasone

(Submitter supplied) PURPOSE. Triamcinolone acetonide (TA) and dexamethasone (DEX) are corticosteroids commonly used for ocular inflammation but both can cause ocular hypertension. We investigated the differential gene expression profile of human trabecular meshwork (TM) cells in response to treatment by TA compared to that by DEX. METHODS. Total RNA was extracted from cultured human TM cells treated with TA or DEX and used for microarray gene expression analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4564
9 Samples
Download data
Series
Accession:
GSE6298
ID:
200006298
6.

Laminin-deficient muscular dystrophy, dy/dy diaphragm

(Submitter supplied) Laminin (merosin) deficient muscular dystrophy in dy/dy mouse diaphragm muscle, 8 weeks old Keywords: muscle, muscular dystrophy, laminin, merosin, diaphragm, mouse
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1778
Platform:
GPL339
8 Samples
Download data
Series
Accession:
GSE3252
ID:
200003252
7.
Full record GDS1778

Alpha2-laminin deficient dy/dy model of muscular dystrophy: diaphragm

Analysis of diaphragms of alpha2-laminin deficient dy/dy animals. Alpha-2 laminin is important in muscle cell attachment, and its deficiency underlies classical congenital muscular dystrophy. Results provide insight into the events that link alpha2-laminin deficiency with muscle fiber necrosis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL339
Series:
GSE3252
8 Samples
Download data
DataSet
Accession:
GDS1778
ID:
1778
8.

Glucocorticoid Induced Changes in Gene Expression in Human Lens Epithelial Cells

(Submitter supplied) Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the short term biological effect of glucocorticoid action in lens epithelial cells is not known. This study seeks to examine glucocorticoid induced changes in global gene expression in LECs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1353
Platform:
GPL96
12 Samples
Download data
Series
Accession:
GSE3040
ID:
200003040
9.
Full record GDS1353

Glucocorticoid effect on lens epithelial cells: time course

Analysis of cultured immortalized lens epithelial cells (LEC) 4 and 16 hours after treatment with 1 uM dexamethasone, a glucocorticoid steroid hormone. Long-term glucocorticoid use can induce cataract formation. Results identify glucocorticoid targets and short-term effects of glucocorticoid on LECs
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 time sets
Platform:
GPL96
Series:
GSE3040
12 Samples
Download data
DataSet
Accession:
GDS1353
ID:
1353
10.

Differential expression of genes after 48 hrs, 10 d, and 3 wks of TAC

(Submitter supplied) Microarray analysis of gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 48 hours, 10 days, and 3 weeks. Keywords: time-course
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS794
Platform:
GPL81
26 Samples
Download data: CEL, EXP
Series
Accession:
GSE1621
ID:
200001621
11.
Full record GDS794

Cardiac hypertrophy progression: time course

Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 3 month old males. Hearts examined 2, 10, and 21 days after surgery. Results provide insight into the progression of cardiac hypertrophy.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol, 3 time sets
Platform:
GPL81
Series:
GSE1621
26 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS794
ID:
794
12.

Placental gene expression in severe preeclampsia.

(Submitter supplied) The series is composed of thirty hybridizations for analysis of differentially expressed genes in normal placenta tissues from patients with normal labor and placenta tissues from patients with severe preeclampsia. Patients tissues samples were obtained from (Vasilis. Total RNA extraction was performed by using the MagNa Pure Compact RNA Isolation Kit (Roche Applied Science). Keywords: Gene expression study, Disease state
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2986
43 Samples
Download data: TXT
Series
Accession:
GSE10588
ID:
200010588
13.

mRNA expression profile in peripheral blood cells of RA patients following treatment with an anti-TNFa mAb, infliximab

(Submitter supplied) Objectives: We monitored the mRNA expression profiles of peripheral blood cells during treatment with a tumor necrosis factor-a inhibitor, infliximab, in patients with rheumatoid arthritis (RA). Using a DNA microarray analysis, we demonstrated a unique set of genes, with distinct baseline and post-treatment changes in expression between responders and non-responders to infliximab treatment.Methods: Using a customized low-density cDNA microarray and a reliable data collection system, we monitored the mRNA expression profiles of whole blood cells from 18 RA patients before and after the infusion of infliximab for up to 22 weeks. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5460
72 Samples
Download data: TXT
Series
Accession:
GSE8350
ID:
200008350
14.

Identification of differentially expressed genes in equine endometrium at day 8 and 12 of pregnancy

(Submitter supplied) In order to systematically analyze the maternal, i.e. the endometrial, changes in the equine endometrium underlying the complex embryo-maternal dialogue during early pregnancy, a transcriptome study of endometrium samples from five mares at day 8 and six mares at day 12 of early pregnancy and the corresponding non-pregnant stage was performed.
Organism:
Equus caballus
Type:
Expression profiling by array
Platform:
GPL10248
22 Samples
Download data: TXT
Series
Accession:
GSE21046
ID:
200021046
15.

Gene expression determination in breast muscle associated with the phenotypic expression of feed efficiency (FE) in a single male broiler line

(Submitter supplied) Gene expression determination between breast muscle associated with the phenotypic expression of feed efficiency (FE) in a single male broiler line. Goal was to determine the changes of gene expression by feed efficiency (FE).
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL8764
4 Samples
Download data: GPR
Series
Accession:
GSE24963
ID:
200024963
16.

Effects of breaking up prolonged sitting on skeletal muscle gene expression

(Submitter supplied) Breaking up prolonged sitting has been shown to be beneficially associated with cardio-metabolic risk markers in both observational and intervention studies. We aimed to define the acute transcriptional events induced in skeletal muscle by breaks in sedentary time. Overweight/obese adults participated in a randomized three-period, three-treatment cross-over trial in an acute setting (5 hours): seated position with no activity, seated with 2-minute bouts of light- or moderate-intensity treadmill walking every 20 minutes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data: TXT
Series
Accession:
GSE39576
ID:
200039576
17.

Normal Heart vs Normal Diaphragm

(Submitter supplied) Comparison of gene expression of heart (left vent) and diaphragm of normal Sprague Dawley rats, young adult Keywords: Cell type comparison
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3224
Platform:
GPL341
12 Samples
Download data: CEL
Series
Accession:
GSE6943
ID:
200006943
18.
Full record GDS3224

Heart left ventricle and diaphragm comparison

Analysis of normal heart left ventricle and diaphragm of young-adult Sprague Dawley males. Concurrent rhythmic contractions of the diaphragm and heart are needed to sustain life. Results provide insight into transcriptional strategies for ensuring long-term energy supplies in these two muscles.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL341
Series:
GSE6943
12 Samples
Download data: CEL
DataSet
Accession:
GDS3224
ID:
3224
19.

Normal rat diaphragm vs sternohyoid

(Submitter supplied) Normal young adult Sprague Dawley rats (male)
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
12 Samples
Download data: CEL
Series
Accession:
GSE12282
ID:
200012282
20.

Effects of exercise on gene expression in human neutrophils

(Submitter supplied) Relatively brief bouts of exercise alter gene expression in peripheral blood mononuclear cells (PBMCs), but whether or not exercise changes gene expression in circulating neutrophils (whose numbers, like PBMCs, increase) is not known. We hypothesized that exercise would activate neutrophil genes involved in apoptosis, inflammation, and cell growth and repair, since these functions in leukocytes are known to be influenced by exercise. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3073
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE8668
ID:
200008668
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