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Links from GEO DataSets

Items: 10

1.
Full record GDS4218

Multiple sclerosis: brain lesions

Analysis of histologically characterized multiple sclerosis (MS) brain lesions. MS is an inflammatory autoimmune disease which progresses to demyelination of the brain and spinal cord. Results provide insight into molecular events during MS pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state, 4 other, 2 tissue sets
Platform:
GPL570
Series:
GSE38010
7 Samples
Download data: CEL
2.

Janus-Like Opposing Roles of CD47 in Autoimmune Brain Inflammation in Human and Mice

(Submitter supplied) Gene transcripts and proteins expressed during disease pathogenesis identify targets for therapy. We performed microarray analysis of histologically characterized multiple sclerosis (MS) brain lesions in comparison with control brain samples to identify differentially expressed molecules. We identified CD47 as a target of interest and studied its biology in MS and EAE.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4218
Platform:
GPL570
7 Samples
Download data: CEL
Series
Accession:
GSE38010
ID:
200038010
3.

Human cerebrospinal fluid autoantibody lipid microarray profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Pseudomonas aeruginosa; Bacillus subtilis; Salmonella enterica subsp. enterica serovar Typhimurium; Streptococcus pyogenes; Mycobacterium tuberculosis; Homo sapiens; Escherichia coli; Staphylococcus aureus; Sus scrofa domesticus; Bos primigenius
Type:
Other
Platforms:
GPL15505 GPL15506 GPL15535
108 Samples
Download data: TXT
Series
Accession:
GSE37830
ID:
200037830
4.

Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2C)

(Submitter supplied) Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. more...
Organism:
Pseudomonas aeruginosa; Mycobacterium tuberculosis; Homo sapiens; Sus scrofa domesticus; Bos primigenius; Escherichia coli; Staphylococcus aureus; Streptococcus pyogenes; Bacillus subtilis; Salmonella enterica subsp. enterica serovar Typhimurium
Type:
Other
Platform:
GPL15535
25 Samples
Download data: TXT
Series
Accession:
GSE37826
ID:
200037826
5.

Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2A)

(Submitter supplied) Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. more...
Organism:
Streptococcus pyogenes; Pseudomonas aeruginosa; Bacillus subtilis; Escherichia coli; Staphylococcus aureus; Sus scrofa domesticus; Bos primigenius; Salmonella enterica subsp. enterica serovar Typhimurium; Mycobacterium tuberculosis; Homo sapiens
Type:
Other
Platform:
GPL15506
24 Samples
Download data: TXT
Series
Accession:
GSE37670
ID:
200037670
6.

Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 1A)

(Submitter supplied) Lipids comprise 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. more...
Organism:
Bacillus subtilis; Salmonella enterica subsp. enterica serovar Typhimurium; Streptococcus pyogenes; Bos primigenius; Pseudomonas aeruginosa; Mycobacterium tuberculosis; Homo sapiens; Escherichia coli; Staphylococcus aureus; Sus scrofa domesticus
Type:
Other
Platform:
GPL15505
59 Samples
Download data: TXT
Series
Accession:
GSE37664
ID:
200037664
7.

The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL14613 GPL6246 GPL10740
36 Samples
Download data: CEL
Series
Accession:
GSE47440
ID:
200047440
8.

Lymph node CD4+ T cell miRNA expression data from naïve C57BL/6J and C57BL/6J-ChrY^SJL

(Submitter supplied) Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of autoimmune disease, including experimental allergic encephalomyelitis (EAE) and experimental myocarditis, correlates with the natural variation in copy number of Sly and Rbmy multicopy ChrY genes. more...
Organism:
Mus musculus; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL14613
6 Samples
Download data: CEL
Series
Accession:
GSE47439
ID:
200047439
9.

Lymph node CD4+ T cell and thioglycollate-elicited peritoneal macrophage expression data from naïve young and old SJL/J and SJL-ChrY^B10.S male mice

(Submitter supplied) Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of autoimmune disease, including experimental allergic encephalomyelitis (EAE) and experimental myocarditis, correlates with the natural variation in copy number of Sly and Rbmy multicopy ChrY genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10740
24 Samples
Download data: CEL
Series
Accession:
GSE47437
ID:
200047437
10.

Lymph node CD4+ T cell expression data from naïve C57BL/6J and C57BL/6J-ChrY^SJL

(Submitter supplied) Understanding the DNA elements that constitute and control the regulatory genome is critical for the appropriate therapeutic management of complex diseases. Here, using chromosome Y (ChrY) consomic mouse strains on the C57BL/6J background, we show that susceptibility to two diverse animal models of autoimmune disease, including experimental allergic encephalomyelitis (EAE) and experimental myocarditis, correlates with the natural variation in copy number of Sly and Rbmy multicopy ChrY genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE47024
ID:
200047024
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