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Links from GEO DataSets

Items: 14

1.
Full record GDS4215

Aging effect on hippocampal regions critical for memory and cognition

Analysis of hippocampal cornu ammonis and dentate gyrus from young and aged female simians. Aging rhesus monkeys develop Metabolic Syndrome (MetS) symptoms and age-related cognitive decline similar to humans. Results provide insight into MetS-associated brain dysfunction in aging.
Organism:
Macaca mulatta
Type:
Expression profiling by array, count, 2 age, 2 tissue sets
Platform:
GPL3535
Series:
GSE11697
23 Samples
Download data: CEL
2.

Young and aged rhesus hippocampal CA1 and DG

(Submitter supplied) Metabolic, mitochondrial and behavioral correlations with transcriptional profiles from the CA1 and DG hippocampal regions of young and aged rhesus macaque. Increasing evidence indicates that obesity correlates with impaired cognitive performance during normal aging and is a major risk factor for Alzheimer’s disease. However, little is known regarding how peripheral metabolic variables affect cellular pathways in brain regions important for memory. more...
Organism:
Macaca mulatta
Type:
Expression profiling by array
Dataset:
GDS4215
Platform:
GPL3535
23 Samples
Download data: CEL, PDF
Series
Accession:
GSE11697
ID:
200011697
3.

Molecular profiles of cognitive aging

(Submitter supplied) Gene expression was measured from the dentate gyrus and entorhinal cortex harvested from human postmortem samples.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
16 Samples
Download data
Series
Accession:
GSE46193
ID:
200046193
4.

Expression data from aged, calorically restricted rat hippocampal regions CA1, CA3, and DG

(Submitter supplied) Aging is associated with a decline in hippocampal mediated learning and memory, a process wich can be ameliorated by dietary (caloric) restriction. We used Affymetrix gene expression analysis to monitor changes in three regions of the hippocampus (CA1, CA3, DG) of middle aged (18 months) and old (28 month) rats that were exposed to dietary restriction. Old rats were determined to be good performers (GP) or poor performers (PP) in behavioral tests to assess thier hippocampal function.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
45 Samples
Download data: CEL, CHP, TXT, XLS
Series
Accession:
GSE21681
ID:
200021681
5.

Transcriptional profiles of rodent hippocampal CA1 tissue during aging and cognitive decline

(Submitter supplied) Recent microarray studies in the hippocampus of rodents or Alzheimer’s disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3915
Platform:
GPL341
49 Samples
Download data: CEL
Series
Accession:
GSE9990
ID:
200009990
6.
Full record GDS3915

Aging and cognitive decline: hippocampus

Analysis of hippocampi from F344 males, at 5 age points across the adult lifespan, tested on the Morris water maze (MWM) task. MWM is a dorsal hippocampal-dependent, spatial memory task. MWM performance showed an age effect. Results provide insight into the molecular basis of cognitive aging.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 5 age sets
Platform:
GPL341
Series:
GSE9990
49 Samples
Download data: CEL
7.

Regional commonalities and specificities of age-related changes in hippocampal transcriptome.

(Submitter supplied) The project examined age-related change in hippocampal gene expression in Fisher 344 x Brown Norway F1 rats from the NIA aging colony (Adult = 12M, Aged = 24M). CA1, CA3, and DG specific dissections were examined from one cohort of animals and from a second cohort whole hippocampus was used.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
60 Samples
Download data: TXT
Series
Accession:
GSE55352
ID:
200055352
8.

Alzheimer's Disease Dataset

(Submitter supplied) This dataset contains microarray data from normal controls (aged 20-99 yrs) and Alzheimer's disease cases, from 4 brain regions: hippocampus, entorhinal cortex, superior frontal cortex, post-central gyrus. Changes in expression of synaptic and immune related genes were analyzed, investigating age-related changes and AD-related changes, and region-specific patterns of change. These AD cases were processed simultaneously with the control cases (young and aged) included in GSE11882 (GSE11882 dataset contains data exclusively from normal control brains).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
253 Samples
Download data: CEL
Series
Accession:
GSE48350
ID:
200048350
9.

Gene expression changes in the course of normal brain aging are sexually dimorphic

(Submitter supplied) This dataset of cognitively normal controls is a subset of the GSE48350 dataset, which additionally contains microarray data from AD brains. Gene expression profiles were assessed in the hippocampus (HC), entorhinal cortex (EC), superior frontal gyrus (SG), and postcentral gyrus (PCG) across the lifespan of 63 cognitively intact individuals from 20-99 years old. New perspectives on the global gene changes that are associated with brain aging emerged, revealing two overarching concepts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
173 Samples
Download data: CEL
Series
Accession:
GSE11882
ID:
200011882
10.

Hippocampal pathways in cognitive impairment

(Submitter supplied) Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways associated with aging-related cognitive impairment. Aged rats were separated into cognitively unimpaired (AU) or impaired (AI) groups, based on their Morris water maze performance relative to young-adult (Y) animals. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2639
Platform:
GPL341
78 Samples
Download data: CEL, EXP, XLS
Series
Accession:
GSE5666
ID:
200005666
11.
Full record GDS2639

Aging and cognitive impairment: hippocampus

Analysis of hippocampi from aged learning-impaired animals on the last day of training in the Morris water maze (MWZ) or 21 days post-training. The MWZ task is a dorsal hippocampal-dependent task. Results provide insight into the molecular basis of aging-related cognitive impairment.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 age, 3 disease state, 3 protocol sets
Platform:
GPL341
Series:
GSE5666
78 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS2639
ID:
2639
12.

Gene Microarrays in Hippocampal Aging

(Submitter supplied) Male Fischer 344 rats aged 4 months (young, n=10), 14 months (mid-aged, n=10), and 24 months (aged, n=10) were trained sequentially on two tasks: Morris Spatial Water Maze (SWM) and Object Memory Task (OMT). The training/testing sequence lasted 7 d, and hippocampal tissue was collected 24 hr later. Training and testing occured on each day except for days 2 and 3 of the 7 d sequence. (01/10/05: Series was updated to correct mislabeling of all sample signal values within the Young Treatment Group) Keywords = bioinformatics Keywords = gene expression Keywords = memory Keywords = synaptic plasticity Keywords = myelin Keywords = inflamation Keywords = aging Keywords: repeat sample
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS520
Platform:
GPL85
29 Samples
Download data: CEL, TXT
Series
Accession:
GSE854
ID:
200000854
13.
Full record GDS520

Hippocampal aging and cognitive impairment

Identification of aging-dependent cognitive decline gene expression. Hippocampal CA1 tissue collected from 4, 14, and 24 month old male Fischer 344 rats after 7 days training on water maze and object memory task.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 age sets
Platform:
GPL85
Series:
GSE854
29 Samples
Download data: CEL, TXT
DataSet
Accession:
GDS520
ID:
520
14.

Hippocampal subfield transcriptomic profiles: Regional vulnerability to age and cognitive impairment

(Submitter supplied) The current study employed next-generation RNA sequencing to examine gene expression related to brain aging and cognitive decline. Young and aged rats were trained on a spatial episodic memory task. Hippocampal regions CA1, CA3 and the dentate gyrus (DG) were isolated. Poly-A mRNA was examined using two different platforms, Illumina and Ion Proton. The Illumina platform was used to generate lists of genes that were differentially expressed across regions, ages, and in association with cognitive function. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19482
102 Samples
Download data: CSV
Series
Accession:
GSE97608
ID:
200097608
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