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Links from GEO DataSets

Items: 20

1.
Full record GDS4146

Subcutaneous Interferon-beta-1b treatment in relapsing-remitting multiple sclerosis (U133 B): peripheral mononuclear blood cells

Temporal analysis of PBMCs collected from 25 German relapsing-remitting multiple sclerosis patients treated with recombinant interferon-beta-1b (rIFN-β-1b, 250 µg every other day) for 2 years. Results provide insight into molecular mechanisms of IFN-b action.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 gender, 5 time sets
Platform:
GPL97
Series:
GSE24427
125 Samples
Download data: CEL
2.

Expression data of multiple sclerosis patients receiving subcutaneous Interferon-beta-1a therapy [U133 Plus 2.0]

(Submitter supplied) The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1a treatment (Rebif, 22 µg or 44 µg three times a week) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 12 MS patients within the first two years of IFN-beta administration.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14837
60 Samples
Download data: CEL
Series
Accession:
GSE33464
ID:
200033464
3.

Expression data of multiple sclerosis patients receiving subcutaneous Interferon-beta-1b therapy [U133 A and B]

(Submitter supplied) The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 25 MS patients within the first two years of IFN-beta administration.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS4145 GDS4146
Platforms:
GPL96 GPL97
250 Samples
Download data: CEL
Series
Accession:
GSE24427
ID:
200024427
4.

Expression data of multiple sclerosis patients receiving intramuscular Interferon-beta-1a therapy [U133 A and B]

(Submitter supplied) The purpose of this study was to characterize the transcriptional effects induced by intramuscular IFN-beta-1a treatment (Avonex, 30 µg once weekly) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 24 MS patients within the first four weeks of IFN-beta administration. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL9741 GPL9742
144 Samples
Download data: CEL
Series
Accession:
GSE19285
ID:
200019285
5.
Full record GDS4145

Subcutaneous Interferon-beta-1b treatment in relapsing-remitting multiple sclerosis (U133 A): peripheral mononuclear blood cells

Temporal analysis of PBMCs collected from 25 German relapsing-remitting multiple sclerosis patients treated with recombinant interferon-beta-1b (rIFN-β-1b, 250 µg every other day) for 2 years. Results provide insight into molecular mechanisms of IFN-b action.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 gender, 5 time sets
Platform:
GPL96
Series:
GSE24427
125 Samples
Download data: CEL
6.

Pharmacogenomics of IFNb therapy

(Submitter supplied) This experiment set is used for the manuscript entitled: Pharmacogenomics of Interferon-b therapy in multiple sclerosis: Baseline IFN signature determines pharmacological differences between patients. In this study we generated and analyzed pre- and post- IFNb treatment gene expression patterns of RRMS patients with the aim of identifying pre-existing and/or drug-induced signatures that will allow us to make predictions on the expected pharmacological effects of IFNb treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6534
32 Samples
Download data
Series
Accession:
GSE10655
ID:
200010655
7.

Expression data of multiple sclerosis patients receiving Interferon-beta therapy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array; Expression profiling by RT-PCR
4 related Platforms
78 Samples
Download data: CEL
Series
Accession:
GSE46293
ID:
200046293
8.

Expression data of multiple sclerosis patients receiving Interferon-beta therapy [TaqMan(r) Array Human MicroRNA B Cards v2.0]

(Submitter supplied) The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS). By using TaqMan Array MicroRNA Cards, we obtained microRNA expression profiles of peripheral blood mononuclear cells from 6 patients within the first month of IFN-beta treatment.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL13329
24 Samples
Download data: XLS
Series
Accession:
GSE46292
ID:
200046292
9.

Expression data of multiple sclerosis patients receiving Interferon-beta therapy [TaqMan(r) Array Human MicroRNA A Cards v2.0]

(Submitter supplied) The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS). By using TaqMan Array MicroRNA Cards, we obtained microRNA expression profiles of peripheral blood mononuclear cells from 6 patients within the first month of IFN-beta treatment.
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL13328
24 Samples
Download data: XLS
Series
Accession:
GSE46283
ID:
200046283
10.

Expression data of multiple sclerosis patients receiving Interferon-beta therapy [miRNA-2_0]

(Submitter supplied) The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS). By using Affymetrix microarrays, we obtained microRNA expression profiles of peripheral blood mononuclear cells from 3 patients within the first month of IFN-beta treatment.
Organism:
Homo sapiens; synthetic construct
Type:
Non-coding RNA profiling by array
Platform:
GPL14613
6 Samples
Download data: CEL
Series
Accession:
GSE46282
ID:
200046282
11.

Expression data of multiple sclerosis patients receiving Interferon-beta therapy [HG-U133_Plus_2]

(Submitter supplied) The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS). By using Affymetrix microarrays, we obtained gene expression profiles of peripheral blood mononuclear cells from 6 patients within the first month of IFN-beta treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15445
24 Samples
Download data: CEL
Series
Accession:
GSE46280
ID:
200046280
12.

Gene expression in PBMC from Multiple Sclerosis patients undergoing interferon beta therapy.

(Submitter supplied) We studied the gene expression patterns in PBMC from relapsing remitting MS patients undergoing weekly IFN-ß-1a therapy. On the basis of two fold changes in expression levels and statistical analyses we selected a diagnostic set of 137 genes that were differentially expressed between pretreatment and IFN-ß-1a-treated MS patients. Some these 137 genes may provide the basis for lack of IFN-ß-1a response. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2419
Platform:
GPL4191
36 Samples
Download data
Series
Accession:
GSE5574
ID:
200005574
13.
Full record GDS2419

Multiple sclerosis response to interferon beta-1a therapy: peripheral blood mononuclear cells

Analysis of peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis (MS) patients 1 day before, 1 day after, and up to 12 months after the initiation of interferon beta-1a (IFN-beta-1a) therapy. Results identify biomarkers for beta-IFN responsiveness.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state, 6 individual, 4 time sets
Platform:
GPL4191
Series:
GSE5574
36 Samples
Download data
DataSet
Accession:
GDS2419
ID:
2419
14.

Profiling of interferon beta immediate transcriptional effects in humans

(Submitter supplied) In this study we used high frequency sampling and DNA microarrays to analyze the longitudinal transcriptional profile of blood cells taken from two individuals only hours after interferon beta administration and up to a week later as compared to samples taken from healthy controls taken at coordinated time points. Keywords: Time series
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4228
130 Samples
Download data
Series
Accession:
GSE5678
ID:
200005678
15.

Gene expression profiling of the response to interferon beta in EBV-transformed and primary B cells of patients with multiple sclerosis

(Submitter supplied) To identify gene expression changes and pathways induced by interferon-β (IFN-β) in B cells, we studied the in vitro response of EBV-transformed B cells (lymphoblast cell lines-LCLs). LCLs were derived from an MS patient repository. Whole genome expression analysis identified 115 genes that were more than two-fold differentially up-regulated following IFN-β exposure, with over 50 novel IFN-β response genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
32 Samples
Download data: TXT
Series
Accession:
GSE58240
ID:
200058240
16.

Gene expression data: Plasmacytoid dendritic cells (pDCs) of healthy donors and MS patientes before and after IFN beta treatment

(Submitter supplied) Multiple Sclerosis (MS) is an immune-mediated chronic inflammatory disease affecting the central nervous system. The cause of MS is not known and the mechanism of IFN-beta, a disease-modifying treatment (DMT) approved for MS, is not well-understood. Oligonucleotide microarrays were used to study gene expression in plasmacytoid denditic cells (pDCs) which are antigen-presenting cells implicated in MS pathogenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
26 Samples
Download data: CEL
Series
Accession:
GSE37750
ID:
200037750
17.

Expression data of multiple sclerosis patients receiving glatiramer acetate therapy [U133 Plus 2.0]

(Submitter supplied) The purpose of this study was to analyze the transcriptional effects induced by glatiramer acetate treatment (GA; Copaxone, 20 mg injected subcutaneously once daily) in blood monocytes of patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of monocytes from 8 MS patients within the first two months of GA administration.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14837
37 Samples
Download data: CEL
Series
Accession:
GSE42763
ID:
200042763
18.

Expression data from multiple sclerosis patients in remission and relapse

(Submitter supplied) Whole-genome expression of peripheral blood leukocytes was measured in 22 patients and 24 controls using the Human Gene 1.0 ST array by Affymetrix
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
68 Samples
Download data: CEL
Series
Accession:
GSE41890
ID:
200041890
19.

Role for ISGF3II in the Antiviral Activity of IFN-gamma

(Submitter supplied) Type-I (e.g. IFN-alpha, IFN-beta) and type-II IFNs (IFN-gamma) have antiviral, antiproliferative, and immunomodulatory properties. Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN-gamma is thought to do so only through STAT1 homodimers while type-I IFNs activate both STAT1- and STAT2-containing complexes such as ISGF3. Here we show that ISGF3II - composed of phosphorylated STAT1, unphosphorylated STAT2, and IRF9 - also plays a role in IFN-gamma-mediated antiviral activity in humans. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1054
6 Samples
Download data: GPR
Series
Accession:
GSE25113
ID:
200025113
20.

Longitudinal expression profiling in whole blood of multiple sclerosis patients and controls

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16209
815 Samples
Download data: CEL
Series
Accession:
GSE41850
ID:
200041850
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