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Items: 2

1.
Full record GDS4078

Acquired paclitaxel-resistant MDA-MB-231 cancer cells response to bexarotene treatment

Analysis of acquired paclitaxel (PTX)-resistant MDA-MB-231 cells treated with bexarotene-PTX or PTX. Retinoid X receptor-selective agonist bexarotene was efficacious in treating chemo-resistant cancer cells. Results provide insight into bexarotene’s role in overcoming acquired drug resistance.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 2 cell type sets
Platform:
GPL96
Series:
GSE12791
16 Samples
Download data: CEL
DataSet
Accession:
GDS4078
ID:
4078
2.

Paclitaxel resistant MDA-MB-231 Cells and resensitization with bexarotene treatment

(Submitter supplied) Acquired drug resistance represents a major challenge in chemo-therapy treatment for various types of cancers. We have found that the retinoid X receptor–selective agonist bexarotene (LGD1069, Targretin) was efficacious in treating chemo-resistant cancer cells. The goal of this microarray study was to understand the mechanism of bexarotene’s role in overcoming acquired drug resistance using human breast cancer cells MDA-MB-231 as a model system and paclitaxel as model compound. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4078
Platform:
GPL96
16 Samples
Download data: CEL
Series
Accession:
GSE12791
ID:
200012791

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