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Links from GEO DataSets

Items: 20

1.
Full record GDS3983

Pancreatic beta cells and panel of primary tissues

Analysis of adult pancreatic beta cell-enriched fractions and duct cell-enriched fractions and other human primary tissues. Results provide insight into conserved beta cell markers for assessment of beta cell phenotype.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 17 tissue sets
Platform:
GPL96
Series:
GSE30803
33 Samples
Download data: CEL
2.

Genome-wide mRNA expression profiles of FACS-purified rat beta cells freshly isolated from control and 24h-fasted rats

(Submitter supplied) The study was designed to capture the in vivo adaptations of nutrient-sensing pancreatic beta cells to fed or fasted (24h) state. Short periods of fasting are thought to mediate the beta cells’ competence for insulin synthesis and secretion. We examined whether it influenced their typical mRNA expression. After 24h of fasting, a 1.5 fold change was detected in 1.5% of all assayed transcripts (p<0.05), with 95% of altered genes (430 of 452) being down-regulated (Fig.6A). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
6 Samples
Download data: CEL
Series
Accession:
GSE30964
ID:
200030964
3.

Genome-wide mRNA profiling of adult human pancreatic beta and duct cells in comparison to other human tissues

(Submitter supplied) Aims: establishment of reference samples to investigate gene expression selective for endocrine or ductal-exocrine cells within the adult human pancreas. To this end, human islet endocrine cells, FACS-enriched in insulin+ cells, (n=3) and human exocrine ductal cells (n=2) are compared on Affymetrix HG133A platform with duplicate hybridizations of a panel of other primary human tissues.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3983
Platform:
GPL96
33 Samples
Download data: CEL
Series
Accession:
GSE30803
ID:
200030803
4.

Hlxb9 regulated genes in pancreatic beta cells

(Submitter supplied) Hlxb9 is a differentiation factor important for neuronal, and pancreatic beta cell differentiation. It is a transcription factor that represses transcription. It's target genes are unknown. The mouse pancreatic beta cell line MIN6 was used to assess the expression of genes de-repressed upon Hlxb9 knockdown.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE32653
ID:
200032653
5.

cDNA microarray data of bovine placenta

(Submitter supplied) Gene expression patterns of bovine placenta from initial to late stage of pregnancy were investigated by using the our custom designed utero-placental cDNA microarray. Keywords: Time course
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL1221
18 Samples
Download data
Series
Accession:
GSE7096
ID:
200007096
6.

Single-cell transcriptomics reveals unique features of human pancreatic islet cell subtypes

(Submitter supplied) We report the single-cell RNA-seq based identification of 6 known human islet cell types (alpha cells, beta cells, delta cells, pp cells, acinar cells and duct cells) based on the expression of known marker genes. We further assess cell type specific gene expression and suggest novel marker genes for several cell types.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
72 Samples
Download data: TSV
Series
Accession:
GSE73727
ID:
200073727
7.

Transcriptome comparison of mouse pancreatic islets cultured at low vs high ambient glucose

(Submitter supplied) Islets are known to respond to changes in ambient glucose. To quantify the transcriptome-wide changes in ambient glucose, we compared transcriptome of islets exposed to low and high glucose.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT
Series
Accession:
GSE58384
ID:
200058384
8.

Comprehensive mouse alpha and beta cell transcriptomes

(Submitter supplied) Rodent models are widely used to study diabetes. Yet, significant gaps remain in our understanding of mouse islet physiology that reduce their accuracy as a model for human islet disease. We generated comprehensive transcriptomes of mouse beta and alpha cells using a novel bitransgenic mouse model generated for this purpose. This enables systematic comparison across thousands of genes between the two major endocrine cell types of the islets of Langerhans whose principal hormones are of cardinal importance for glucose homeostasis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT
Series
Accession:
GSE54973
ID:
200054973
9.

Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro

(Submitter supplied) Expansion of beta cells from the limited number of adult human islet donors is an attractive prospect for increasing cell availability for cell therapy of diabetes. However, while evidence supports the replicative capacity of adult beta cells in vivo, attempts at expanding human islet cells in tissue culture resulted in loss of beta-cell phenotype. Using a genetic lineage-tracing approach we have provided evidence for massive proliferation of beta-cell-derived (BCD) cells within these cultures. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3984
Platform:
GPL6244
11 Samples
Download data: CEL
Series
Accession:
GSE30732
ID:
200030732
10.
Full record GDS3984

Insulin-Producing Cells generated from dedifferentiated pancreatic islet cells expanded in vitro

Analysis of insulin-producing cells generated from expanded dedifferentiated islet cells induced with Redifferentiation Cocktail (RC). Results provide insight into molecular mechanisms underlying RC-induced phenotypic change in expanded islet cells towards the phenotype of uncultured islet cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 cell type, 3 growth protocol sets
Platform:
GPL6244
Series:
GSE30732
11 Samples
Download data: CEL
11.

Genome-wide mRNA expression profiles of FACS-enriched rat beta cells freshly isolated from neonatal (postnatal day 2-3) and adult (10 weeks-old) Wistar rats

(Submitter supplied) The lower glucose-responsiveness of neonatal beta cells is generally considered a sign of endocrine immaturity. We compared mRNA profiles of neonatal and 10-weeks old rat beta cells to see how their gene expression changes with functional maturation. Neonatal beta cells showed a lower glucose-inducible increment in insulin production than adult cells. This was in part explained by basal protein synthetic hyperactivity of neonatal cells: while at 2.5mM glucose 80% of neonatal beta cells were recruited into active protein synthesis, 10 mM glucose was required to achieve a similar fraction of active adult beta cells. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4937
Platform:
GPL1355
11 Samples
Download data: CEL
Series
Accession:
GSE47174
ID:
200047174
12.
Full record GDS4937

Neonatal and adult pancreatic beta cells

Analysis of β-cells from neonatal (postnatal day 2-3) and adult (10 wk old) Wistar rats. Neonatal β-cells are developmentally immature and, therefore, less glucose responsive. Results provide insight into molecular mechanisms underlying the acquisition of mature glucose responsiveness.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 age, 2 cell type sets
Platform:
GPL1355
Series:
GSE47174
11 Samples
Download data: CEL
DataSet
Accession:
GDS4937
ID:
4937
13.

Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL10558 GPL8179
46 Samples
Download data
Series
Accession:
GSE42095
ID:
200042095
14.

Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation (mRNA)

(Submitter supplied) The remarkable differentiation capacity of pluripotent stem cells into any adult cell types have enabled researchers to model human embryonic development and disease process in dishes, as well as deriving specialized cells for replacing damaged tissues. Type 1 diabetes is a degenerative disease characterized by autoimmune destruction of the insulin-producing beta islet cells in the pancreas. Recent advances have led to the establishment of different methods to direct differentiation of human or mouse pluripotent stem cells toward beta cell lineages. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
23 Samples
Download data: TXT
Series
Accession:
GSE42094
ID:
200042094
15.

Dynamic regulation of miRNA and mRNA signatures during in vitro pancreatic differentiation (miRNA)

(Submitter supplied) The remarkable differentiation capacity of pluripotent stem cells into any adult cell types have enabled researchers to model human embryonic development and disease process in dishes, as well as deriving specialized cells for replacing damaged tissues. Type 1 diabetes is a degenerative disease characterized by autoimmune destruction of the insulin-producing beta islet cells in the pancreas. Recent advances have led to the establishment of different methods to direct differentiation of human or mouse pluripotent stem cells toward beta cell lineages. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8179
23 Samples
Download data: TXT
Series
Accession:
GSE42093
ID:
200042093
16.

Human embryonic stem cells, differerentiated EBs and adult cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Macacine gammaherpesvirus 4; Mus musculus; Human gammaherpesvirus 8; Rattus norvegicus; Macaca mulatta polyomavirus 1
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL7088 GPL7089
38 Samples
Download data: GPR
Series
Accession:
GSE12250
ID:
200012250
17.

microRNA expression profiling among human embryonic stem cells, differerentiated EBs and adult cells

(Submitter supplied) Human embryonic stem (hES) cells have unique features: self-renewal ability and pluripotency. They can be continuously cultured in undifferentiated state and give rise to cells and tissues of all three germ layers. Thus hES cells provide a resource not only for cell replacement therapy but also for studying human developmental biology. We aimed to identify the unique signature of miRNAs in human embryonic stem cells. more...
Organism:
Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Rattus norvegicus; Macacine gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL7089
21 Samples
Download data: GPR
Series
Accession:
GSE12229
ID:
200012229
18.

Gene expression profiling among human embryonic stem cells, differerentiated EBs and adult cells

(Submitter supplied) Human embryonic stem (hES) cells have unique features: self-renewal ability and pluripotency. They can be continuously cultured in undifferentiated state and give rise to cells and tissues of all three germ layers. Thus hES cells provide a resource not only for cell replacement therapy but also for studying human developmental biology. However, much work needs to be done to understand the molecular mechanisms responsible for the maintenance of the undifferentiatiation state and the differentiation process of human embryonic stem cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7088
17 Samples
Download data: GPR
Series
Accession:
GSE12228
ID:
200012228
19.

Transcriptome Profiling and Sequencing of differentiated Human Hematopoietic Stem cells Reveal Lineage Specific Expression and Alternative Splicing of Genes

(Submitter supplied) Hematopoietic differentiation is strictly regulated by complex network of transcription factors that are controlled by ligands binding to cell surface receptors. Disruptions of the intricate sequences of transcriptional activation and suppression of multiple genes cause hematological diseases, such as leukemias, myelodysplastic syndromes or myeloproliferative syndromes. From a clinical standpoint, deciphering the pattern of gene expression during hematopoiesis may help unravel disease-specific mechanisms in hematopoietic malignancies. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5188
12 Samples
Download data: CEL
Series
Accession:
GSE29989
ID:
200029989
20.

Identification of a neuronal gene expression signature: Role of cell-cycle arrest in murine neuronal differentiation in vitro

(Submitter supplied) Stem cells are a potential key strategy for treating neurodegenerative diseases in which the generation of new neurons is critical. A better understanding of the characteristics and molecular properties of neural stem cells (NSC) and differentiated neurons can help in assessing neuronal maturity and possibly in devising better therapeutic strategies. We have therefore performed an in-depth gene expression profiling study of the C17.2 NSC line and primary neurons (PN) derived from embryonic mouse brains. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
9 Samples
Download data: TIFF, TXT
Series
Accession:
GSE24116
ID:
200024116
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