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Links from GEO DataSets

Items: 20

1.
Full record GDS3716

Breast cancer: histologically normal breast epithelium

Analysis of histological normal breast epithelia from both ER- and ER+ breast cancer patients and prophylactic mastectomy patients, and normal breast epithelia from reduction mammoplasty patients. Results provide insight into the mechanisms underlying breast cancer initiation and progression.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 4 specimen sets
Platform:
GPL96
Series:
GSE20437
42 Samples
Download data: CEL
2.

Histologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients

(Submitter supplied) Gene expression in histologically normal epithelium from breast cancer patients and cancer-free prophylactic mastectomy patients share a similar profile Introduction: We hypothesized that gene expression in histologically normal epithelium (NlEpi) would differ in breast cancer patients (HN) compared to usual-risk controls undergoing reduction mammoplasty (RM), and that gene expression in NlEpi from cancer-free prophylactic mastectomies from high-risk women (PM), would resemble HN gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3716
Platform:
GPL96
42 Samples
Download data: CEL
Series
Accession:
GSE20437
ID:
200020437
3.

Gene expression profiles of breast cancer subtypes are detectable in histologically normal breast epithelium

(Submitter supplied) Background: We hypothesize that important genomic differences between breast cancer subtypes occur early in carcinogenesis. Therefore, gene expression might distinguish histologically normal breast epithelium (NlEpi) from breasts containing estrogen receptor positive (ER+) compared with estrogen receptor negative (ER-) cancers. Methods: We examined gene expression in 46 cases of microdissected NlEpi from previously untreated women undergoing breast cancer surgery. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
30 Samples
Download data: CEL, TXT
Series
Accession:
GSE21947
ID:
200021947
4.

Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients

(Submitter supplied) Normal-appearing epithelium of cancer patients can harbor occult genetic abnormalities. Data comprehensively comparing gene expression between histologically normal breast epithelium of breast cancer patients and cancer-free controls are limited. The present study compares global gene expression between these groups. We performed microarrays using RNA from microdissected histologically normal terminal ductal-lobular units (TDLU) from 2 groups: (i) cancer normal (CN) (TDLUs adjacent to untreated ER1 breast cancers (n = 14)) and (ii) reduction mammoplasty (RM) (TDLUs of age-matched women without breast disease (n = 15)). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3139
Platform:
GPL96
29 Samples
Download data: CEL
Series
Accession:
GSE9574
ID:
200009574
5.
Full record GDS3139

Breast cancer: histologically normal breast epithelium

Analysis of histologically normal breast epithelia of breast cancer patients. Results provide insight into the molecular abnormalities in normal appearing breast epithelium in breast cancer and the roles these abnormalities play in carcinogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL96
Series:
GSE9574
29 Samples
Download data: CEL
DataSet
Accession:
GDS3139
ID:
3139
6.

Early Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression

(Submitter supplied) Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer. To better understand their relationship to more advanced disease, we used microdissection and DNA microarrays to profile the gene expression of patient-matched histologically normal (HN), ADH, and DCIS from 12 patients with ER+ sporadic breast cancer. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
40 Samples
Download data: CEL
Series
Accession:
GSE16873
ID:
200016873
7.

aCGH data from age-dichotomized ER+ breast tumors

(Submitter supplied) To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, DNA samples from matched ER+ invasive breast cancers diagnosed in either young (<45) or old (>70) women were analyzed with aCGH Keywords: biomarker identification
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL4999
71 Samples
Download data: XLS
Series
Accession:
GSE8801
ID:
200008801
8.

Expression data from age-dichotomized ER+ breast tumors

(Submitter supplied) To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, RNA samples from matched ER+ invasive breast cancers diagnosed in either young (≤45) or old (≥70) women were analyzed by expression microarrays Keywords: biomarker identification
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4685
47 Samples
Download data: CEL
Series
Accession:
GSE8193
ID:
200008193
9.

Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer

(Submitter supplied) The contralateral unaffected breast of women with unilateral breast cancer (cases) is a good model for defining subtype-specific risk since women with ER-negative index primaries are at high risk for subsequent ER-negative primary cancers. We performed random fine needle aspiration (rFNA) of the unaffected breasts of cases; samples from 30 subjects (15 ER-positive and 15 ER-negative cases matched for age, race and menopausal status), were used for Illumina expression array analysis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
30 Samples
Download data: TXT
Series
Accession:
GSE41400
ID:
200041400
10.

In Silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome

(Submitter supplied) We present a method for identifying and ascribing differentially expressed genes to tumor epithelial and/or stromal cells, by utilizing pathologic information and weighted t-statistics
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2986
213 Samples
Download data: TXT
Series
Accession:
GSE24117
ID:
200024117
11.

Analysis of microdissected invasive lobular and ductal breast carcinomas in relation to normal ductal and lobular cells

(Submitter supplied) The aim of our study was to identify gene expression profiles of ductal and lobular carcinomas in relation to normal ductal and lobular cells. We examined ten mastectomy specimens from postmenopausal breast cancer patients. Ductal and lobular tumor and normal cells were microdissected from cryosections. Fifty nanograms of total RNA were amplified and labeled by PCR and in vitro transcription. GCOS pairwise comparison algorithm and rank products have identified multiple genes that are differentially expressed in comparisons between ductal and lobular tumor and normal cell types. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2635
Platform:
GPL570
30 Samples
Download data: CEL, EXP
Series
Accession:
GSE5764
ID:
200005764
12.
Full record GDS2635

Invasive ductal and lobular breast carcinomas

Analysis of invasive ductal carcinoma (IDC) cells, invasive lobular carcinoma (ILC) cells, and their normal counterparts. Cells obtained from postmenopausal breast cancer patients. Results provide insight into the molecular differences between IDC and ILC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL570
Series:
GSE5764
30 Samples
Download data: CEL, EXP
13.

Gene expression data from non-malignant fallopian tube epithelium and high grade serous carcinoma.

(Submitter supplied) The purpose of this study was to identify molecular alterations potentially involved in predisposition to adnexal serous carcinoma (SerCa) in the non-malignant fallopian tube epithelium (FTE) of BRCA1/2-mutation carriers, given recent evidence implicating the distal FTE as a common source for SerCa. Keywords: disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
37 Samples
Download data: CEL
Series
Accession:
GSE10971
ID:
200010971
14.

microRNAs and their target proteins are associated with characteristics of estrogen receptor-positive breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL5639 GPL13746
16 Samples
Download data: GPR
Series
Accession:
GSE38280
ID:
200038280
15.

microRNAs and their target proteins associated with characteristics of estrogen receptor-positive breast cancer (mRNA data)

(Submitter supplied) Recent analyses have identified heterogeneity in estrogen receptor (ER)-positive breast cancer. There are so-called luminal A and luminal B subtypes, and the characteristics, such as response to endocrine therapy and chemotherapy and prognosis, are different in these two subtypes of breast cancer. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissues were compared between highly and incompletely endocrine responsive tumors by miRNA and mRNA microarrays. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5639
8 Samples
Download data: GPR
Series
Accession:
GSE38279
ID:
200038279
16.

microRNAs and their target proteins are associated with characteristics of estrogen receptor-positive breast cancer (miRNA data)

(Submitter supplied) Recent analyses have identified heterogeneity in estrogen receptor (ER)-positive breast cancer. There are so-called luminal A and luminal B subtypes, and the characteristics, such as response to endocrine therapy and chemotherapy and prognosis, are different in these two subtypes of breast cancer. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissues were compared between highly and incompletely endocrine responsive tumors by miRNA and mRNA microarrays. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL13746
8 Samples
Download data: GPR
Series
Accession:
GSE38278
ID:
200038278
17.

Expression data from non-malignant fallopian tube epithelium

(Submitter supplied) Microarrays were used to examine gene expression changes that may be present in the fallopian tube epithelium of morphologically normal BRCA1 mutation positive and negative subjects. Fallopian tube epithelia has been implicated as an early point of origin for serous carcninoma. By examining the early events present in the microenvironment of this tissue between BRCA1 mutation carriers and non-carriers, we hoped to elucidate mechanisms that may lead to the development of epithelial ovarian cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE28044
ID:
200028044
18.

Parity and the genomic signature in the Human Breast

(Submitter supplied) Case-control study for the analysis of the gene expression profile of epithelial cells microdissected from normal breast tissues obtained from 17 parous and 7 nulliparous women free of breast pathology (controls), and 39 parous and 8 nulliparous women with history of breast cancer (cases). Keywords: genetic modifications
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL7384 GPL7392 GPL7393
210 Samples
Download data: TXT
Series
Accession:
GSE13293
ID:
200013293
19.

Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL8432 GPL6883
50 Samples
Download data
Series
Accession:
GSE23386
ID:
200023386
20.

Gene profiling using archival formalin-fixed paraffin-embedded breast cancer specimens can generate informative microarray data: A comparison with matched fresh fine needle aspiration biopsy samples (FNA samples)

(Submitter supplied) The Formalin-Fixed Paraffin-Embedded (FFPE) samples on selected breast cancer subtypes (ER+/Her2-, ER+/Her2+, ER-/Her2+, and ER-/Her2-) and their paired fresh fine needle aspirated biopsies (FNA) were investigated. The cases represented different subtypes of breast cancers based on their clinical receptors ER (E) and Her2 (H) status to demonstrate the ability of gene profiles to differentiate these tumors. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6883
25 Samples
Download data: TXT
Series
Accession:
GSE23385
ID:
200023385
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